KCNE4 and FLNA

Number of citations of the paper that reports this interaction (PMID 20498229)
2

Data Source:
BioGRID (two hybrid)

		KCNE4	FLNA
Gene Name		potassium channel, voltage gated subfamily E regulatory beta subunit 4	filamin A, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Apical Plasma Membrane	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite
	Molecular Function	Voltage-gated Potassium Channel Activity	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly
Pathways			Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Waist circumference ( 20966902)
Protein-Protein Interactions		6 interactors: FLNA KCNA1 KCNQ1 OBSL1 PRKCA TSNAX	82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG
Entrez ID		23704	2316
HPRD ID		09689	02060
Ensembl ID		ENSG00000152049	ENSG00000196924
Uniprot IDs		A5H1P5 B7Z275	P21333 Q60FE5 Q6NXF2
PDB IDs			2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH
Enriched GO Terms of Interacting Partners?		Regulation Of Muscle Contraction Action Potential Potassium Ion Export Across Plasma Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Positive Regulation Of Dense Core Granule Biogenesis Synaptic Transmission Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Heart Contraction Detection Of Abiotic Stimulus Sensory Perception Of Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiovascular System Development Cellular Response To Magnesium Ion Neuronal Signal Transduction Platelet Activation Cell-cell Signaling Cell Junction Assembly Potassium Ion Transport Sensory Perception Of Touch Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Positive Regulation Of Cardiac Muscle Contraction Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Membrane Potential Desmosome Assembly Atrial Cardiac Muscle Cell Action Potential Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Atrial Cardiac Muscle Cell To AV Node Cell Communication Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Positive Regulation Of Striated Muscle Contraction Potassium Ion Export Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation MRNA Transcription From RNA Polymerase II Promoter Desmosome Organization Developmental Process Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cell Communication By Electrical Coupling MRNA Transcription Negative Regulation Of Transport Cell-cell Signaling Involved In Cardiac Conduction Magnesium Ion Homeostasis Negative Regulation Of Glucose Transport Cellular Response To Epinephrine Stimulus	Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Intersection) ?