KCNE4 and KCNA1

Number of citations of the paper that reports this interaction (PMID 12944270)
11

Data Source:
HPRD (in vitro)

		KCNE4	KCNA1
Gene Name		potassium channel, voltage gated subfamily E regulatory beta subunit 4	potassium channel, voltage gated shaker related subfamily A, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Apical Plasma Membrane	Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Dendrite Paranode Region Of Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Juxtaparanode Region Of Axon Synapse
	Molecular Function	Voltage-gated Potassium Channel Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Transmembrane Transporter Activity
	Biological Process	Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Potassium Ion Transport Regulation Of Muscle Contraction Synaptic Transmission Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Neuronal Signal Transduction Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport
Pathways			Potassium Channels Voltage gated Potassium channels
Drugs			Enflurane Amitriptyline Isoflurane Methoxyflurane Nifedipine Desflurane Sevoflurane Dalfampridine
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Waist circumference ( 20966902)
Protein-Protein Interactions		6 interactors: FLNA KCNA1 KCNQ1 OBSL1 PRKCA TSNAX	3 interactors: DLG1 DLG4 KCNE4
Entrez ID		23704	3736
HPRD ID		09689	08885
Ensembl ID		ENSG00000152049	ENSG00000111262
Uniprot IDs		A5H1P5 B7Z275	Q09470
PDB IDs			2AFL
Enriched GO Terms of Interacting Partners?		Regulation Of Muscle Contraction Action Potential Potassium Ion Export Across Plasma Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Positive Regulation Of Dense Core Granule Biogenesis Synaptic Transmission Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Heart Contraction Detection Of Abiotic Stimulus Sensory Perception Of Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiovascular System Development Cellular Response To Magnesium Ion Neuronal Signal Transduction Platelet Activation Cell-cell Signaling Cell Junction Assembly Potassium Ion Transport Sensory Perception Of Touch Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Positive Regulation Of Cardiac Muscle Contraction Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Membrane Potential Desmosome Assembly Atrial Cardiac Muscle Cell Action Potential Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Atrial Cardiac Muscle Cell To AV Node Cell Communication Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Positive Regulation Of Striated Muscle Contraction Potassium Ion Export Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation MRNA Transcription From RNA Polymerase II Promoter Desmosome Organization Developmental Process Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cell Communication By Electrical Coupling MRNA Transcription Negative Regulation Of Transport Cell-cell Signaling Involved In Cardiac Conduction Magnesium Ion Homeostasis Negative Regulation Of Glucose Transport Cellular Response To Epinephrine Stimulus	Receptor Localization To Synapse Protein Localization To Synapse Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Ion Transmembrane Transport Receptor Clustering Nucleotide Phosphorylation Regulation Of Ion Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Membrane Potential T Cell Cytokine Production Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Protein Localization To Membrane Maintenance Of Apical/basal Cell Polarity Axon Guidance Negative Regulation Of Receptor Internalization Peristalsis Cytokine Production Involved In Immune Response Immunological Synapse Formation Locomotory Exploration Behavior Dendritic Spine Morphogenesis Synaptic Vesicle Maturation Maintenance Of Cell Polarity Axonogenesis Nucleotide Metabolic Process Axon Development Vocalization Behavior Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Amyloid Precursor Protein Metabolic Process Chemotaxis Actin Cytoskeleton Organization Membrane Raft Organization Dendritic Spine Development Neuron Projection Morphogenesis Endothelial Cell Proliferation Actin Filament-based Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Dendritic Spine Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Exploration Behavior Postsynaptic Membrane Organization
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcnd2 kcnj3 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcnd2 kcnj3 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Intersection) ?