KCNE4

Description		potassium voltage-gated channel subfamily E regulatory subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Appendicular lean mass ( 33097823) Body mass index ( 20966902) Coronary artery disease in type 1 diabetes ( 32077919) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Fasting plasma glucose ( 32902719) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Recurrent major depressive disorder x sex interaction ( 34099189) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX
Entrez ID		23704
HPRD ID		09689
Ensembl ID		ENSG00000152049
Uniprot IDs		Q8WWG9
PDB IDs
Enriched GO Terms of Interacting Partners?		GET Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Metal Ion Transport Regulation Of Muscle System Process Endoplasmic Reticulum Tail-anchored Membrane Protein Insertion Into ER Membrane Transmembrane Transporter Binding Regulation Of Membrane Potential Monoatomic Cation Transport Monoatomic Ion Transport Membrane Repolarization During Action Potential Delayed Rectifier Potassium Channel Activity Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Muscle Contraction Membrane Repolarization Detection Of Mechanical Stimulus Involved In Sensory Perception Protein Insertion Into ER Membrane Regulation Of Biological Quality Positive Regulation Of Potassium Ion Transport Response To Mechanical Stimulus Regulation Of Membrane Repolarization Regulation Of System Process Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Detection Of Mechanical Stimulus Renal Absorption Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Regulation Of Monoatomic Cation Transmembrane Transport Homeostatic Process Regulation Of Platelet Activation Voltage-gated Potassium Channel Activity Inorganic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Perinuclear Region Of Cytoplasm Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Gastrin-induced Gastric Acid Secretion Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Protein Insertion Into Membrane Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Transport Neuronal Cell Body Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transport
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