PDCD6IP and SH3GL3

Number of citations of the paper that reports this interaction (PubMedID 12034747)
0

Data Source:
HPRD (two hybrid, in vivo)

		PDCD6IP	SH3GL3
Description		programmed cell death 6 interacting protein	SH3 domain containing GRB2 like 3, endophilin A3
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Extracellular Exosome Anchoring Junction Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle	Acrosomal Vesicle Cytoplasm Endosome Early Endosome Membrane Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Cell Division Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Extracellular Exosome Biogenesis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 18391951 28552196 25282103 20397748 18391950) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Smoking initiation ( 33082346) Spine bone size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		43 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 LRRN1 MAPK6 NEDD4L NEURL2 NUP155 PDCD6 PTK2B RAMP3 RNF10 RNF11 SDCBP SDCBP2 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SNCA SRC SUMO2 TAB1 TSG101 TTF2 VPS28 VPS37C WWP2 YES1	52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33
Entrez ID		10015	6457
HPRD ID		06425	04528
Ensembl ID		ENSG00000170248	ENSG00000140600
Uniprot IDs		Q8WUM4	Q99963
PDB IDs		2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?		Endosome Viral Budding Via Host ESCRT Complex Viral Budding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle-mediated Transport Multivesicular Body Assembly Multivesicular Body Organization Establishment Of Protein Localization Late Endosome To Vacuole Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Proteolysis Involved In Protein Catabolic Process Endocytosis Protein Transport Endosome Organization Cytoplasm Regulation Of Endocytosis Multivesicular Body Macromolecule Catabolic Process Biological Process Involved In Interaction With Host Macroautophagy Endosomal Transport Receptor-mediated Endocytosis Import Into Cell Midbody Abscission Cellular Localization Establishment Of Localization In Cell Regulation Of MAPK Cascade Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Intracellular Transport Viral Release From Host Cell Receptor Internalization Vesicle Organization Protein Metabolic Process Positive Regulation Of MAPK Cascade Viral Process Late Endosome Membrane ESCRT I Complex ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Plasma Membrane Synaptic Vesicle Endocytosis Cytokinetic Process Regulation Of Organelle Assembly	Presynapse Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Presynaptic Cytosol Central Nervous System Development Cytoplasmic Side Of Mitochondrial Outer Membrane Cytoplasm Negative Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Vocal Learning Observational Learning Synapse
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