PDCD6IP and NUP155

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		PDCD6IP	NUP155
Description		programmed cell death 6 interacting protein	nucleoporin 155
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Extracellular Exosome Anchoring Junction Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle	Nucleus Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Membrane Nuclear Pore Inner Ring
	Molecular Function	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Cell Division Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Extracellular Exosome Biogenesis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Envelope Organization Protein Transport Protein Localization To Nucleus MiRNA Processing Protein Localization To Nuclear Inner Membrane MRNA Transport Atrial Cardiac Muscle Cell Action Potential
Pathways		Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	Malaria ( 31844061) Meat-related diet ( 32066663)
Interacting Genes		43 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 LRRN1 MAPK6 NEDD4L NEURL2 NUP155 PDCD6 PTK2B RAMP3 RNF10 RNF11 SDCBP SDCBP2 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SNCA SRC SUMO2 TAB1 TSG101 TTF2 VPS28 VPS37C WWP2 YES1	7 interacting genes: CDC42 EFS GLE1 NUP35 PDCD6IP UBC ZFYVE9
Entrez ID		10015	9631
HPRD ID		06425	05984
Ensembl ID		ENSG00000170248	ENSG00000113569
Uniprot IDs		Q8WUM4	B4DLT2 E9PF10 O75694
PDB IDs		2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3	5A9Q 5IJN 5IJO 7EYE 7EYF 7EYQ 7PER 7R1Y 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Endosome Viral Budding Via Host ESCRT Complex Viral Budding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle-mediated Transport Multivesicular Body Assembly Multivesicular Body Organization Establishment Of Protein Localization Late Endosome To Vacuole Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Proteolysis Involved In Protein Catabolic Process Endocytosis Protein Transport Endosome Organization Cytoplasm Regulation Of Endocytosis Multivesicular Body Macromolecule Catabolic Process Biological Process Involved In Interaction With Host Macroautophagy Endosomal Transport Receptor-mediated Endocytosis Import Into Cell Midbody Abscission Cellular Localization Establishment Of Localization In Cell Regulation Of MAPK Cascade Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Intracellular Transport Viral Release From Host Cell Receptor Internalization Vesicle Organization Protein Metabolic Process Positive Regulation Of MAPK Cascade Viral Process Late Endosome Membrane ESCRT I Complex ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Plasma Membrane Synaptic Vesicle Endocytosis Cytokinetic Process Regulation Of Organelle Assembly	Apolipoprotein A-I Receptor Binding Cellular Localization Endothelin Receptor Signaling Pathway Involved In Heart Process Focal Adhesion Establishment Or Maintenance Of Apical/basal Cell Polarity Centrosome Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Establishment Of Localization In Cell Intracellular Transport Establishment Or Maintenance Of Cell Polarity RNA Transport Inositol Hexakisphosphate Binding Nuclear Pore Cytoplasmic Filaments Phospholipid Binding MRNA Transport Nuclear Pore Extracellular Vesicle Biogenesis Extracellular Exosome Biogenesis Nucleus Organization Positive Regulation Of Extracellular Exosome Assembly Proteinase Activated Receptor Binding Actomyosin Contractile Ring Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell-cell Junction Organization Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Extracellular Exosome Assembly Nuclear Pore Central Transport Channel Intracellular Protein Localization Nucleobase-containing Compound Transport Nuclear Envelope Establishment Of Golgi Localization Protein Domain Specific Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Leading Edge Membrane Thioesterase Binding Neuron Fate Determination Golgi Transport Complex Actomyosin Nuclear Transport Nucleocytoplasmic Transport Endothelin Receptor Signaling Pathway Cell Junction Assembly Cytosol
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