PDCD6IP and PDCD6

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		PDCD6IP	PDCD6
Description		programmed cell death 6 interacting protein	programmed cell death 6
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Extracellular Exosome Anchoring Junction Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Cell Division Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Extracellular Exosome Biogenesis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination
Pathways		Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
Drugs			Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		43 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 LRRN1 MAPK6 NEDD4L NEURL2 NUP155 PDCD6 PTK2B RAMP3 RNF10 RNF11 SDCBP SDCBP2 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SNCA SRC SUMO2 TAB1 TSG101 TTF2 VPS28 VPS37C WWP2 YES1	29 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CEBPA CPNE1 CPNE2 CPNE4 DIAPH3 FAS FASLG FNDC3A HEBP2 IGFALS KLHL12 MAP3K5 MAPK1IP1L MIA2 PDCD6IP PEF1 PRR19 SARAF SEC31A SH3KBP1 SHISA4 TIMM22 UBC VPS37C YWHAQ
Entrez ID		10015	10016
HPRD ID		06425	03035
Ensembl ID		ENSG00000170248	ENSG00000249915
Uniprot IDs		Q8WUM4	A0A024QZ42 A0A087WZ38 O75340 Q53FC3
PDB IDs		2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3	2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ
Enriched GO Terms of Interacting Partners?		Endosome Viral Budding Via Host ESCRT Complex Viral Budding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle-mediated Transport Multivesicular Body Assembly Multivesicular Body Organization Establishment Of Protein Localization Late Endosome To Vacuole Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Proteolysis Involved In Protein Catabolic Process Endocytosis Protein Transport Endosome Organization Cytoplasm Regulation Of Endocytosis Multivesicular Body Macromolecule Catabolic Process Biological Process Involved In Interaction With Host Macroautophagy Endosomal Transport Receptor-mediated Endocytosis Import Into Cell Midbody Abscission Cellular Localization Establishment Of Localization In Cell Regulation Of MAPK Cascade Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Intracellular Transport Viral Release From Host Cell Receptor Internalization Vesicle Organization Protein Metabolic Process Positive Regulation Of MAPK Cascade Viral Process Late Endosome Membrane ESCRT I Complex ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Plasma Membrane Synaptic Vesicle Endocytosis Cytokinetic Process Regulation Of Organelle Assembly	Response To Metal Ion Calcium-dependent Protein Binding Response To Calcium Ion Calcium-dependent Phospholipid Binding Extracellular Exosome COPII Vesicle Coat Endoplasmic Reticulum Exit Site Vesicle Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Necroptotic Signaling Pathway Vesicle-mediated Transport Phosphatidylserine Binding ESCRT I Complex Vesicle Organization Cellular Response To Metal Ion Replicative Senescence Cellular Response To Calcium Ion Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor Viral Budding Via Host ESCRT Complex Membrane Organization COPII Vesicle Coating Cellular Localization Viral Budding Autophagy Lymphocyte Apoptotic Process T Cell Apoptotic Process NF-kappaB Binding Ligase Inhibitor Activity Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Vesicle Cargo Loading Golgi Vesicle Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Negative Regulation Of MRNA Modification Multivesicular Body Organization Multivesicular Body Assembly Stem Cell Development Neural Crest Cell Development Vesicle Coating Stereocilia Tip-link Density COPII-coated ER To Golgi Transport Vesicle Cytokinetic Process Apoptotic Signaling Pathway
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