PDCD6IP and TAB1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PDCD6IP	TAB1
Gene Name		programmed cell death 6 interacting protein	TGF-beta activated kinase 1/MAP3K7 binding protein 1
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Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Microtubule Organizing Center Cytosol Focal Adhesion Membrane Vesicle Melanosome Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Protein Complex
	Molecular Function	Protein Binding SH3 Domain Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding	Catalytic Activity Protein Binding Enzyme Activator Activity Kinase Activator Activity Protein Complex Binding Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Cell Separation After Cytokinesis Apoptotic Process Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Process Viral Life Cycle Viral Budding Via Host ESCRT Complex Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Extracellular Vesicular Exosome Assembly	Activation Of MAPKKK Activity Activation Of MAPK Activity In Utero Embryonic Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Heart Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Lung Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways		HIV Life Cycle Budding and maturation of HIV virion Uptake and actions of bacterial toxins HIV Infection Uptake and function of anthrax toxins Late Phase of HIV Life Cycle	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)	IgG glycosylation ( 23382691) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		35 interactors: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 EGFR F2R GRB2 HOXA1 ITSN1 ITSN2 KEAP1 MAPK6 PDCD6 PTK2B RAMP3 RNF11 SDCBP SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SRC TAB1 TNIP2 TSG101 TTF2 VPS28 VPS37C YES1	61 interactors: ACAP3 ARAP1 ASRGL1 BMPR1A C2orf44 C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 EPRS FADD FN1 GIT1 HNRNPR KIFC2 LAP3 LCMT1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 URB1 WTAP XIAP XPO7 YWHAG ZMYND11
Entrez ID		10015	10454
HPRD ID		06425	04012
Ensembl ID		ENSG00000170248	ENSG00000100324
Uniprot IDs		C5MQH7 Q8WUM4	A8K6K3 Q15750
PDB IDs		2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 4JJY	2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L53
Enriched GO Terms of Interacting Partners?		Virion Assembly Locomotion Endocytosis Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Cell Migration Cell Separation After Cytokinesis Membrane Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Viral Budding Transport Regulation Of Signal Transduction Viral Life Cycle Regulation Of Cellular Process Establishment Of Protein Localization Endosomal Transport Viral Protein Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of ERBB Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Viral Process Axon Development Regulation Of Signaling Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of MAPK Cascade Neuron Projection Morphogenesis Regulation Of Intracellular Signal Transduction Cell Projection Organization Response To Organic Substance Multicellular Organismal Development Regulation Of Organelle Organization Response To External Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Positive Regulation Of Metabolic Process Intracellular Transport Neuron Development Anatomical Structure Development Apoptotic Process Cell Morphogenesis Involved In Differentiation	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Catalytic Activity Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorus Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Intracellular Signal Transduction Immune Response Positive Regulation Of MAP Kinase Activity Activation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Signal Transduction By Phosphorylation Apoptotic Process Stress-activated MAPK Cascade
Tagcloud ?		129n 146n adjuvanted arepanrix batch batches deamidation dige dioxidation fabp focetria gallus glycosylation h1n1 ha1 ha2 hemagglutinin latticed ma1 manufacturing narcolepsy neuraminidase nucleoprotein pandemrix ph1n1 sulfation tspan8 tub vaccines	5z attenuated ccr7 chemokine collectively constitutive ikappab ikk importantly invasion jnk jun lymphatic mb mda mediator motif o orthotopic oxozeaenol p38 phospho promotes repressed strongly suppressed tak1 tgf unclear
Tagcloud (Difference) ?		129n 146n adjuvanted arepanrix batch batches deamidation dige dioxidation fabp focetria gallus glycosylation h1n1 ha1 ha2 hemagglutinin latticed ma1 manufacturing narcolepsy neuraminidase nucleoprotein pandemrix ph1n1 sulfation tspan8 tub vaccines	5z attenuated ccr7 chemokine collectively constitutive ikappab ikk importantly invasion jnk jun lymphatic mb mda mediator motif o orthotopic oxozeaenol p38 phospho promotes repressed strongly suppressed tak1 tgf unclear
Tagcloud (Intersection) ?