ZDHHC17 and SREBF2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		ZDHHC17	SREBF2
Description		zDHHC palmitoyltransferase 17	sterol regulatory element binding transcription factor 2
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP-Insig Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	C-8 Sterol Isomerase Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Negative Regulation Of Amyloid-beta Clearance Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)	Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 27680694 31043758) Caffeine consumption from tea ( 33287642) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		23390	6721
HPRD ID		09697	02726
Ensembl ID		ENSG00000186908	ENSG00000198911
Uniprot IDs		A8KA01 Q8IUH5	Q12772
PDB IDs		3EU9 5W7I 5W7J	1UKL
Enriched GO Terms of Interacting Partners?		Protein Binding	Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Signal Transduction Enzyme Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Cholesterol Metabolic Process SUMO Transferase Activity Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Metabolic Process Rhythmic Process PML Body Transcription Cis-regulatory Region Binding Regulation Of Intracellular Transport Regulation Of Protein Stability Regulation Of Lipid Biosynthetic Process Presynaptic Cytosol Negative Regulation Of RNA Metabolic Process
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