ZDHHC17 and TNFSF10

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		ZDHHC17	TNFSF10
Description		zDHHC palmitoyltransferase 17	TNF superfamily member 10
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding TRAIL Binding Metal Ion Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Signaling TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Liver volume ( 34128465) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	10 interacting genes: ACP5 CASP3 CFTR RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
Entrez ID		23390	8743
HPRD ID		09697	04670
Ensembl ID		ENSG00000186908	ENSG00000121858
Uniprot IDs		A8KA01 Q8IUH5	P50591 Q6IBA9
PDB IDs		3EU9 5W7I 5W7J	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?		Protein Binding	TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Apoptotic Process Programmed Cell Death Activation Of NF-kappaB-inducing Kinase Activity Cell Surface Apoptotic Signaling Pathway Golgi-associated Vesicle Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity Signaling Receptor Activity Negative Regulation Of Superoxide Anion Generation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRAIL Receptor Activity Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Phospholipase A2 Activator Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protease Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Monoatomic Anion Transport Multicellular Organismal-level Homeostasis Anterior Neural Tube Closure Cellular Response To Staurosporine Positive Regulation Of Enamel Mineralization Positive Regulation Of Protein Kinase Activity Luteolysis Glial Cell Apoptotic Process Transepithelial Water Transport Positive Regulation Of Kinase Activity Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Immune System Process Acid Phosphatase Activity Response To Anesthetic Positive Regulation Of Tooth Mineralization Protein-cysteine S-stearoyltransferase Activity Ferric Iron Binding Death-inducing Signaling Complex
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