ZDHHC17 and SHOX2

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		ZDHHC17	SHOX2
Description		zDHHC palmitoyltransferase 17	SHOX homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Chromatin Nucleus
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Regulation Of Heart Rate Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Chondrocyte Development Sinoatrial Node Development Heart Valve Development Sinoatrial Valve Development Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Digestive Tract Morphogenesis Embryonic Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Axonogenesis Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Muscle Tissue Morphogenesis Cardiac Pacemaker Cell Differentiation Sinoatrial Node Cell Development Stem Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)	Appendicular lean mass ( 33097823) Body mass index ( 26426971) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 25429064 31562340) Idiopathic dilated cardiomyopathy ( 29495422) Lung cancer in never smokers ( 28604730) Monobrow ( 27182965) Neurociticism ( 29500382) Neuroticism ( 29255261) Pulse pressure ( 30224653)
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	3 interacting genes: CDK4 TRIM29 ZDHHC17
Entrez ID		23390	6474
HPRD ID		09697	03936
Ensembl ID		ENSG00000186908	ENSG00000168779
Uniprot IDs		A8KA01 Q8IUH5	O60902
PDB IDs		3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		Protein Binding	Phylloquinone Catabolic Process 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity NADPH Dehydrogenase (quinone) Activity Vitamin K Catabolic Process Cyclin D2-CDK4 Complex Cyclin D1-CDK4 Complex Cellular Response To Ionomycin Cyclin D3-CDK4 Complex Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sorting Endosome Post-embryonic Camera-type Eye Morphogenesis Endocardium Development Vascular Endothelial Growth Factor Binding Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carbonyl Reductase (NADPH) Activity Vitamin K Metabolic Process Cellular Response To Ether Regulation Of Type B Pancreatic Cell Proliferation Response To Phorbol 13-acetate 12-myristate Cellular Response To Phorbol 13-acetate 12-myristate Lymph Vessel Development Positive Regulation Of Membrane Depolarization Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Nitric Oxide Mediated Signal Transduction Endothelium Development Vascular Wound Healing Positive Regulation Of Vasculogenesis Positive Regulation Of Mitochondrial Depolarization Regulation Of CGMP-mediated Signaling Regulation Of Bone Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Golgi-associated Vesicle Membrane Ketone Catabolic Process NADPH Binding Regulation Of Epithelial Cell Proliferation
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