ZDHHC17 and NPFF

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		ZDHHC17	NPFF
Description		zDHHC palmitoyltransferase 17	neuropeptide FF-amide peptide precursor
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus Postsynapse Neuronal Dense Core Vesicle
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Neuropeptide Activity
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Response To Xenobiotic Stimulus Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion
Pathways			Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17
Entrez ID		23390	8620
HPRD ID		09697	06869
Ensembl ID		ENSG00000186908	ENSG00000139574
Uniprot IDs		A8KA01 Q8IUH5	O15130
PDB IDs		3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		Protein Binding	Neuropeptide Signaling Pathway Neuropeptide Receptor Activity G Protein-coupled Receptor Activity Short-day Photoperiodism Regulation Of MAPK Cascade Perforant Pathway To Dendrate Granule Cell Synapse G Protein-coupled Receptor Signaling Pathway Regulation Of Nerve Growth Factor Production Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Neuropeptide Y Receptor Binding Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Opioid Receptor Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Eating Behavior Monocyte Activation Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Intestinal Epithelial Cell Differentiation Adult Feeding Behavior Positive Regulation Of Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Signaling Receptor Binding Golgi-associated Vesicle Membrane Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Lipoprotein Transport Protein Palmitoylation Regulation Of Dopamine Metabolic Process Modulation Of Chemical Synaptic Transmission Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Intracellular Signal Transduction Regulation Of Feeding Behavior Photoperiodism Protein Lipidation Positive Regulation Of Behavior
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