ZDHHC17 and DLK1

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		ZDHHC17	DLK1
Description		zDHHC palmitoyltransferase 17	delta like non-canonical Notch ligand 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Extracellular Space Cytoplasm Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	Calcium Ion Binding Protein Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	Cell Differentiation Negative Regulation Of Notch Signaling Pathway
Pathways			Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body size at age 10 ( 32376654) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Height ( 31562340) Hodgkin's lymphoma ( 34216518) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 29403010 22139419) Refractive error ( 32231278) Type 1 diabetes ( 19966805) Type 2 diabetes ( 32499647)
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	3 interacting genes: GAS1 GRN ZDHHC17
Entrez ID		23390	8788
HPRD ID		09697	01446
Ensembl ID		ENSG00000186908	ENSG00000185559
Uniprot IDs		A8KA01 Q8IUH5	A8K019 P80370
PDB IDs		3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		Protein Binding	Regulation Of Programmed Cell Death Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Aspartic-type Peptidase Activity Trophectodermal Cell Proliferation Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Protein-cysteine S-myristoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Respiratory Burst Protein-cysteine S-stearoyltransferase Activity Negative Regulation Of Neutrophil Activation Cerebellar Climbing Fiber To Purkinje Cell Synapse Regulation Of Proteolysis Positive Regulation Of Axon Regeneration Negative Regulation Of Microglial Cell Activation Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Folding Regulation Of Neutrophil Activation Positive Regulation Of Peptidase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Oxysterol Binding Lysosomal Protein Catabolic Process Locomotory Exploration Behavior Regulation Of Defense Response To Bacterium Regulation Of Lysosome Organization Macrophage Activation Involved In Immune Response Regulation Of Microglial Cell Activation Positive Regulation Of Defense Response To Bacterium Astrocyte Activation Regulation Of Inflammatory Response To Wounding Protein Catabolic Process In The Vacuole Negative Regulation Of Macrophage Activation Regulation Of Respiratory Burst Negative Regulation Of Neuroinflammatory Response Lipoprotein Transport Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Lysosomal Lumen Acidification
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