ZDHHC17 and APBB1IP

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ZDHHC17	APBB1IP
Description		zDHHC palmitoyltransferase 17	amyloid beta precursor protein binding family B member 1 interacting protein
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium T Cell Receptor Complex Cell Projection Anchoring Junction
	Molecular Function	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity	Protein Binding
	Biological Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Signal Transduction Positive Regulation Of Cell Adhesion
Pathways			Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory biomarkers ( 22228203) Lymphocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Response to angiotensin II receptor blocker therapy ( 22566498) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9	11 interacting genes: BAG6 EVL GAS7 HRAS NDN PFN1 PRPF40A RAP1A TLX3 VASP ZDHHC17
Entrez ID		23390	54518
HPRD ID		09697	16420
Ensembl ID		ENSG00000186908	ENSG00000077420
Uniprot IDs		A8KA01 Q8IUH5	Q7Z5R6
PDB IDs		3EU9 5W7I 5W7J	2MWN 3ZDL
Enriched GO Terms of Interacting Partners?		Protein Binding	Regulation Of Ruffle Assembly Developmental Process Positive Regulation Of Actin Filament Polymerization GDP Binding Modulation Of Chemical Synaptic Transmission Profilin Binding Positive Regulation Of Protein Polymerization Glutamatergic Synapse Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Respiratory Gaseous Exchange By Respiratory System Neurotrophin Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Cell Projection Assembly System Development Brain Development Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Small GTPase-mediated Signal Transduction Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Actin Filament Bundle Assembly Protein Homotetramerization Actin Polymerization Or Depolymerization Perforant Pathway To Dendrate Granule Cell Synapse G Protein-coupled Glycine Receptor Activity Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Epithelial Cell Migration G Protein Activity Regulation Of Cell Projection Organization Regulation Of Biological Quality GTPase Complex Response To Antineoplastic Agent Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Postsynaptic Golgi Apparatus
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