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TNS2 and ERBB2
Number of citations of the paper that reports this interaction (PMID
16273093
)
170
Data Source:
BioGRID
(unspecified method)
TNS2
ERBB2
Gene Name
tensin 2
erb-b2 receptor tyrosine kinase 2
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Nucleus
Cytoplasm
Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Receptor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Binding
Metal Ion Binding
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Receptor Signaling Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Biological Process
Kidney Development
Negative Regulation Of Cell Proliferation
Response To Muscle Activity
Dephosphorylation
Cellular Homeostasis
Collagen Metabolic Process
Multicellular Organism Growth
Intracellular Signal Transduction
Multicellular Organismal Homeostasis
Positive Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Signal Transduction By Phosphorylation
Positive Regulation Of Cell Growth
Positive Regulation Of Rho GTPase Activity
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription From RNA Polymerase I Promoter
Positive Regulation Of Transcription From RNA Polymerase III Promoter
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Axon guidance
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Innate Immune System
Signaling by PDGF
Downregulation of ERBB2:ERBB3 signaling
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Semaphorin interactions
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Trastuzumab
Lapatinib
ado-trastuzumab emtansine
Pertuzumab
Afatinib
Diseases
GWAS
Protein-Protein Interactions
28 interactors:
AXL
BRCA1
C11orf87
C19orf66
CRKL
CSNK1E
ERBB2
ERBB3
FGFR1
GFI1B
ITGB3
ITGB5
ITGB7
KIF1A
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP12-2
NUBP2
PKP1
REEP6
REL
TBC1D16
TEKT5
ZNF250
ZNF417
ZNF587
110 interactors:
ABL1
ABL2
ACPP
ANKS1A
ANKS1B
APBB1
APBB3
BCAR3
BLK
BLNK
BMX
BTC
CAV1
CBL
CD82
CHN1
CISH
CLNK
CRK
CRKL
CTNNB1
DAB1
DLG4
DOK1
DOK4
DOK6
EGF
EGFR
ERBB2IP
ERBB3
ERBB4
ERRFI1
ESR1
FER
FGR
GRAP2
GRB2
GRB7
HDAC6
HLA-A
HSP90AA1
HSP90B1
IL6ST
IRS1
IRS4
ITGA5
ITGB4
ITK
JAK1
JAK2
JUP
MAPK8IP1
MAPK8IP2
MATK
MUC1
MUC4
NCK2
NF2
NRG1
PAK1
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PTK2
PTK2B
PTPN11
PTPN18
RASA1
RIN1
RIN2
SERPINA3
SH2B2
SH2B3
SH2D1B
SH2D2A
SH2D3A
SH2D5
SH3BGRL3
SH3BP2
SHC1
SHC2
SHC3
SLA
SLA2
SOCS1
SOS1
SRC
SRPK1
STAT1
STAT3
STUB1
SUPT6H
SYK
TEC
TGFA
TLN1
TNS2
TNS3
TOB1
TXK
UBB
USP2
VAV1
VAV2
VAV3
Entrez ID
23371
2064
HPRD ID
16256
01281
Ensembl ID
ENSG00000111077
ENSG00000141736
Uniprot IDs
Q63HR2
P04626
PDB IDs
2DKQ
2KNO
2L6K
2LOZ
3HQC
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
4GFU
Enriched GO Terms of Interacting Partners
?
Immune System Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Neurotrophin Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Kinase Activity
Regulation Of Signaling
Positive Regulation Of Protein Modification Process
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Transferase Activity
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Protein Metabolic Process
Response To Growth Factor
Regulation Of Histone H3-K4 Methylation
Integrin-mediated Signaling Pathway
Regulation Of Transcription From RNA Polymerase III Promoter
Heterotypic Cell-cell Adhesion
Phosphatidylinositol 3-kinase Signaling
Regulation Of Cellular Process
Phosphatidylinositol-mediated Signaling
Signal Transduction
Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell-matrix Adhesion
Regulation Of Intracellular Signal Transduction
Regulation Of Kinase Activity
Innate Immune Response
Cell Surface Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Signaling
Multicellular Organismal Development
Intracellular Signal Transduction
Cellular Response To Organic Substance
Viral Entry Into Host Cell
Positive Regulation Of Phosphorylation
Response To Organic Substance
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Signal Transduction
Cell Communication
Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cellular Response To Stimulus
Intracellular Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Response To Stimulus
Regulation Of Immune Response
Fc Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Immune Response
Regulation Of Immune System Process
Defense Response
Immune System Process
Cellular Response To Organic Substance
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Response To Stress
Peptidyl-tyrosine Autophosphorylation
Regulation Of Catalytic Activity
Response To Organic Substance
Cellular Response To Organonitrogen Compound
Fc-epsilon Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Regulation Of Cellular Process
Cellular Response To Peptide
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Locomotion
Neurotrophin Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Catalytic Activity
Movement Of Cell Or Subcellular Component
Cell Motility
Cell Migration
Wound Healing
Response To Peptide Hormone
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?