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TNS2 and ERBB3
Number of citations of the paper that reports this interaction (PMID
16273093
)
170
Data Source:
BioGRID
(unspecified method)
TNS2
ERBB3
Gene Name
tensin 2
erb-b2 receptor tyrosine kinase 3
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Receptor Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Binding
Metal Ion Binding
Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Kidney Development
Negative Regulation Of Cell Proliferation
Response To Muscle Activity
Dephosphorylation
Cellular Homeostasis
Collagen Metabolic Process
Multicellular Organism Growth
Intracellular Signal Transduction
Multicellular Organismal Homeostasis
Endocardial Cushion Development
Protein Phosphorylation
Negative Regulation Of Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Peripheral Nervous System Development
Heart Development
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Schwann Cell Differentiation
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cranial Nerve Development
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Regulation Of Cell Proliferation
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Negative Regulation Of Secretion
Neuron Apoptotic Process
Positive Regulation Of Protein Tyrosine Kinase Activity
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Type 1 diabetes (
19430480
18198356
17554260
17554300
18978792
)
Type 1 diabetes autoantibodies (
21829393
)
Vitiligo (
22951725
)
Protein-Protein Interactions
28 interactors:
AXL
BRCA1
C11orf87
C19orf66
CRKL
CSNK1E
ERBB2
ERBB3
FGFR1
GFI1B
ITGB3
ITGB5
ITGB7
KIF1A
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP12-2
NUBP2
PKP1
REEP6
REL
TBC1D16
TEKT5
ZNF250
ZNF417
ZNF587
66 interactors:
ABL1
ABL2
AGTR2
BCAR3
CD82
CDK5
CHN2
CRK
CRKL
DAB1
DAPP1
EGF
EGFR
EGR1
ERBB2
ERBB4
FER
FGFR1
FLNA
FLYWCH1
GRB2
GRB7
HCK
HDAC6
IL6ST
ITK
JAK2
JAK3
MUC1
NCK1
NCK2
NEDD4
NRG1
NRG2
ODF2L
PA2G4
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTGES3
PTK2
PTK2B
PTK6
RASA1
RASA4
RGS4
RIN1
RNF41
RPN1
SH2B3
SH2D1A
SHC1
SHC3
SOS1
SRC
SYK
TNS2
TNS3
TNS4
TXK
VAV1
VAV2
VAV3
ZAP70
ZNF207
Entrez ID
23371
2065
HPRD ID
16256
01820
Ensembl ID
ENSG00000111077
ENSG00000065361
Uniprot IDs
Q63HR2
P21860
PDB IDs
2DKQ
2KNO
2L6K
2LOZ
3HQC
1M6B
2L9U
3KEX
3LMG
3P11
4LEO
Enriched GO Terms of Interacting Partners
?
Immune System Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Neurotrophin Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Kinase Activity
Regulation Of Signaling
Positive Regulation Of Protein Modification Process
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Transferase Activity
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Protein Metabolic Process
Response To Growth Factor
Regulation Of Histone H3-K4 Methylation
Integrin-mediated Signaling Pathway
Regulation Of Transcription From RNA Polymerase III Promoter
Heterotypic Cell-cell Adhesion
Phosphatidylinositol 3-kinase Signaling
Regulation Of Cellular Process
Phosphatidylinositol-mediated Signaling
Signal Transduction
Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell-matrix Adhesion
Regulation Of Intracellular Signal Transduction
Regulation Of Kinase Activity
Innate Immune Response
Cell Surface Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Signaling
Multicellular Organismal Development
Intracellular Signal Transduction
Cellular Response To Organic Substance
Viral Entry Into Host Cell
Positive Regulation Of Phosphorylation
Response To Organic Substance
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Fc Receptor Signaling Pathway
ERBB Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Cell Communication
Immune Response-regulating Signaling Pathway
Regulation Of Signal Transduction
Signaling
Regulation Of Signaling
Cell Migration
Signal Transduction
Immune Response
Regulation Of Immune Response
Peptidyl-tyrosine Autophosphorylation
Cell Motility
Locomotion
Positive Regulation Of Signal Transduction
Regulation Of Immune System Process
Intracellular Signal Transduction
Defense Response
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Phosphorylation
Immune System Process
Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Autophosphorylation
Peptidyl-tyrosine Phosphorylation
Cellular Response To Stimulus
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Fc-epsilon Receptor Signaling Pathway
Movement Of Cell Or Subcellular Component
Positive Regulation Of Metabolic Process
Cellular Response To Organic Substance
Cell Activation
Response To Growth Factor
Response To Stress
Positive Regulation Of Catalytic Activity
Response To Stimulus
Wound Healing
Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Regulation Of Cell Proliferation
Blood Coagulation
Hemostasis
Tagcloud
?
acquire
alteration
associate
cascades
concurrent
dependence
egf
enhancing
latent
mapk
mediators
p42
p44
phosphotyrosine
potentiates
potentiating
predicts
prime
priming
progestin
progestins
r5020
shc
shift
stat5
steroid
switches
synergistically
waf1
Tagcloud (Difference)
?
acquire
alteration
associate
cascades
concurrent
dependence
egf
enhancing
latent
mapk
mediators
p42
p44
phosphotyrosine
potentiates
potentiating
predicts
prime
priming
progestin
progestins
r5020
shc
shift
stat5
steroid
switches
synergistically
waf1
Tagcloud (Intersection)
?