TNS2 and AXL

Number of citations of the paper that reports this interaction (PMID 12470648)
18

Data Source:
HPRD (in vivo, two hybrid)

		TNS2	AXL
Gene Name		tensin 2	AXL receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding	Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Kidney Development Negative Regulation Of Cell Proliferation Response To Muscle Activity Dephosphorylation Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Intracellular Signal Transduction Multicellular Organismal Homeostasis	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Spermatogenesis Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways			Signaling by VEGF VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AXL BRCA1 C11orf87 C19orf66 CRKL CSNK1E ERBB2 ERBB3 FGFR1 GFI1B ITGB3 ITGB5 ITGB7 KIF1A KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 NUBP2 PKP1 REEP6 REL TBC1D16 TEKT5 ZNF250 ZNF417 ZNF587	21 interactors: ADAM10 CBL FBXO25 GAS6 GRB2 IL15RA IL2RG LCK NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3
Entrez ID		23371	558
HPRD ID		16256	00171
Ensembl ID		ENSG00000111077	ENSG00000167601
Uniprot IDs		Q63HR2	M0R0W6 P30530
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	2C5D
Enriched GO Terms of Interacting Partners?		Immune System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cell-substrate Adhesion Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Histone H3-K4 Methylation Integrin-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase III Promoter Heterotypic Cell-cell Adhesion Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Process Phosphatidylinositol-mediated Signaling Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Innate Immune Response Cell Surface Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Multicellular Organismal Development Intracellular Signal Transduction Cellular Response To Organic Substance Viral Entry Into Host Cell Positive Regulation Of Phosphorylation Response To Organic Substance	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Growth Factor Blood Coagulation Hemostasis Cellular Response To Organic Substance Response To Peptide Hormone Cellular Response To Organonitrogen Compound Locomotion Response To Organic Substance Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Insulin Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Cell Migration Wound Healing Movement Of Cell Or Subcellular Component Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Signal Transduction Cell Motility Response To Insulin Response To Wounding Regulation Of Phosphorylation Immune System Process Signaling Platelet Activation Cell Communication Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
Tagcloud ?			antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?			antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Intersection) ?