TNS2 and ITGB5

Number of citations of the paper that reports this interaction (PubMedID 12606711)
45

Data Source:
HPRD (in vitro)

		TNS2	ITGB5
Description		tensin 2	integrin subunit beta 5
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion Membrane Anchoring Junction	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Lipid Binding Hydrolase Activity Kinase Binding Identical Protein Binding Metal Ion Binding	Virus Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Metal Ion Binding
	Biological Process	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal-level Homeostasis	Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Stress Fiber Assembly Symbiont Entry Into Host Cell Epithelial Cell-cell Adhesion Cell-cell Adhesion
Pathways			Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
Drugs
Diseases
GWAS			Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837	58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655
Entrez ID		23371	3693
HPRD ID		16256	00949
Ensembl ID		ENSG00000111077	ENSG00000082781
Uniprot IDs		Q63HR2	L7RT22 P18084
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	7S46 7S47 7S48
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Receptor Complex Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Nucleus Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Basal Plasma Membrane Ruffle Membrane Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process ERBB2 Signaling Pathway Cell-substrate Adhesion Salivary Gland Morphogenesis ERBB3:ERBB2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Keratin Filament Intermediate Filament Focal Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Cell Adhesion Actin Binding Z Disc Negative Regulation Of Programmed Cell Death Anchoring Junction Regulation Of Cell-substrate Adhesion Integrin Binding Cytoskeleton Organization Structural Molecule Activity Transforming Growth Factor Beta Binding Structural Constituent Of Skin Epidermis Positive Regulation Of Cell-substrate Adhesion M Band Protein Binding Wound Healing, Spreading Of Cells Extracellular Matrix Binding Actin Cytoskeleton Organization Supramolecular Fiber Organization Detection Of Muscle Stretch Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Actin Filament-based Process Growth Factor Binding Ruffle Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Migration Tissue Development Positive Regulation Of Cell Motility Regulation Of Apoptotic Process Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Osteoblast Proliferation Microfibril Positive Regulation Of Bone Resorption Calcium Ion Binding Transcription Coregulator Activity Actin Crosslink Formation Cytoskeleton Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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