TNS2 and GATA1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		TNS2	GATA1
Description		tensin 2	GATA binding protein 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion Membrane Anchoring Junction	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Lipid Binding Hydrolase Activity Kinase Binding Identical Protein Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal-level Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Bone Mineralization Negative Regulation Of Bone Mineralization Animal Organ Regeneration Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development System Development Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Sertoli Cell Development Primitive Erythrocyte Differentiation Platelet Aggregation Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Follicle-stimulating Hormone Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS			Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837	86 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PIAS4 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		23371	2623
HPRD ID		16256	02372
Ensembl ID		ENSG00000111077	ENSG00000102145
Uniprot IDs		Q63HR2	P15976
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	6G0Q
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Receptor Complex Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Nucleus Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Basal Plasma Membrane Ruffle Membrane Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process ERBB2 Signaling Pathway Cell-substrate Adhesion Salivary Gland Morphogenesis ERBB3:ERBB2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process NpBAF Complex NBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosome Disassembly Regulation Of G0 To G1 Transition Protein-DNA Complex Disassembly Transcription Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Brahma Complex RSC-type Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process BBAF Complex Protein Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Nucleoplasm Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of Double-strand Break Repair Regulation Of Myoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Differentiation Chromatin Remodeling
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