TNS2 and FGFR1

Number of citations of the paper that reports this interaction (PMID 15117958)
9

Data Source:
HPRD (in vitro, in vivo)

		TNS2	FGFR1
Gene Name		tensin 2	fibroblast growth factor receptor 1
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Kidney Development Negative Regulation Of Cell Proliferation Response To Muscle Activity Dephosphorylation Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Intracellular Signal Transduction Multicellular Organismal Homeostasis	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Transcription, DNA-templated Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by FGFR in disease Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants Signaling by FGFR mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AXL BRCA1 C11orf87 C19orf66 CRKL CSNK1E ERBB2 ERBB3 FGFR1 GFI1B ITGB3 ITGB5 ITGB7 KIF1A KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 NUBP2 PKP1 REEP6 REL TBC1D16 TEKT5 ZNF250 ZNF417 ZNF587	45 interactors: BNIP2 CREBBP CRK CTPS2 EPHA4 ERBB3 FDPS FGF1 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 IL17RD ITK KPNB1 MMP2 NCAM1 NCK1 NCK2 NEDD4 NRP1 PIK3R1 PIK3R2 PLCG1 PTK6 RPS6KA1 RPS6KA3 RTN3 SH3BP2 SHC1 SLA SOS1 TNS2 VAV1
Entrez ID		23371	2260
HPRD ID		16256	00634
Ensembl ID		ENSG00000111077	ENSG00000077782
Uniprot IDs		Q63HR2	P11362
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65
Enriched GO Terms of Interacting Partners?		Immune System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cell-substrate Adhesion Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Histone H3-K4 Methylation Integrin-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase III Promoter Heterotypic Cell-cell Adhesion Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Process Phosphatidylinositol-mediated Signaling Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Innate Immune Response Cell Surface Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Multicellular Organismal Development Intracellular Signal Transduction Cellular Response To Organic Substance Viral Entry Into Host Cell Positive Regulation Of Phosphorylation Response To Organic Substance	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc Receptor Signaling Pathway Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Immune Response Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Defense Response Cell Surface Receptor Signaling Pathway Response To Insulin Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Immune System Process Cellular Response To Peptide Signal Transduction Cellular Response To Organonitrogen Compound Response To Organic Substance Signaling Cell Communication Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cellular Response To Stimulus Response To Stress Locomotion Positive Regulation Of Signal Transduction Response To Organonitrogen Compound System Development Chemotaxis Multicellular Organismal Development Cell Differentiation Response To Hormone Regulation Of Phosphorylation Anatomical Structure Development
Tagcloud ?			abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings
Tagcloud (Difference) ?			abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings
Tagcloud (Intersection) ?