SYNM and PKNOX1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SYNM	PKNOX1
Description		synemin	PBX/knotted 1 homeobox 1
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Adherens Junction Membrane Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton Anchoring Junction	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)	Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		6 interacting genes: DES DTNA ERBB2 ERBB3 ERBB4 PKNOX1	56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3
Entrez ID		23336	5316
HPRD ID		07305	03653
Ensembl ID		ENSG00000182253	ENSG00000160199
Uniprot IDs		A0A075B7B1 O15061	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs		6EWO	1X2N
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Junction ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Basolateral Plasma Membrane Animal Organ Development Growth Factor Binding Intermediate Filament Cytoskeleton Heart Development Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Protein Localization To Synapse Embryonic Pattern Specification Glial Cell Development Negative Regulation Of Apoptotic Process Protein-containing Complex Localization Negative Regulation Of Programmed Cell Death Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Of Planar Polarity Involved In Nephron Morphogenesis Neuron Differentiation Plasma Membrane Regulation Of Epithelial Cell Proliferation Wound Healing Protein Localization To Cell Junction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development Central Nervous System Morphogenesis Nerve Growth Factor Production	Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding
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