SYNM and DES

Number of citations of the paper that reports this interaction (PMID 11353857)
18

Data Source:
HPRD (in vitro)

		SYNM	DES
Gene Name		synemin, intermediate filament protein	desmin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intermediate Filament Adherens Junction Membrane Costamere Neurofilament Cytoskeleton	Cytosol Intermediate Filament Fascia Adherens Z Disc Neuromuscular Junction Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Intermediate Filament Cytoskeleton Organization	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DES DTNA	23 interactors: AURKB BRCA1 CAPN1 CRYAB DSP EHHADH ITSN1 MAPKAPK2 NEB PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I
Entrez ID		23336	1674
HPRD ID		07305	00514
Ensembl ID		ENSG00000182253	ENSG00000175084
Uniprot IDs		O15061	P17661 Q53SB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Neuromuscular Synaptic Transmission Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Striated Muscle Contraction Regulation Of Heart Contraction	Regulation Of Cytoskeleton Organization Intermediate Filament-based Process Apoptotic Process Programmed Cell Death Cell Death Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Developmental Process Response To Abiotic Stimulus Multicellular Organismal Development Muscle Contraction Execution Phase Of Apoptosis Anatomical Structure Development Muscle System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cellular Component Organization Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Cell Death System Development Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process G2 DNA Damage Checkpoint Negative Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Cytoskeleton Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Lipid Response To Steroid Hormone Actin-mediated Cell Contraction Intracellular Signal Transduction Cellular Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Histone H4-K20 Methylation Metanephric Distal Tubule Morphogenesis Positive Regulation Of Histone H4-K16 Acetylation Primary Spermatocyte Growth Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Programmed Cell Death Cell Cycle Checkpoint Chromosome Segregation Axonogenesis Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Development Proteasomal Protein Catabolic Process
Tagcloud ?			airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Difference) ?			airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Intersection) ?