SYNM and DTNA

Number of citations of the paper that reports this interaction (PubMedID 11353857)
36

Data Source:
HPRD (two hybrid, in vitro)

		SYNM	DTNA
Description		synemin	dystrobrevin alpha
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Adherens Junction Membrane Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton Anchoring Junction	Nucleoplasm Cytoplasm Plasma Membrane Membrane Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcolemma Cell Projection Intermediate Filament Cytoskeleton Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding	Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding
	Biological Process	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling
Pathways			Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)
Interacting Genes		6 interacting genes: DES DTNA ERBB2 ERBB3 ERBB4 PKNOX1	16 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN
Entrez ID		23336	1837
HPRD ID		07305	03141
Ensembl ID		ENSG00000182253	ENSG00000134769
Uniprot IDs		A0A075B7B1 O15061	A0A7P0T9L1 A0A7P0TBH9 A0A7P0Z4D7 B7Z3X3 Q9Y4J8
PDB IDs		6EWO	2E5R
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Junction ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Basolateral Plasma Membrane Animal Organ Development Growth Factor Binding Intermediate Filament Cytoskeleton Heart Development Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Protein Localization To Synapse Embryonic Pattern Specification Glial Cell Development Negative Regulation Of Apoptotic Process Protein-containing Complex Localization Negative Regulation Of Programmed Cell Death Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Of Planar Polarity Involved In Nephron Morphogenesis Neuron Differentiation Plasma Membrane Regulation Of Epithelial Cell Proliferation Wound Healing Protein Localization To Cell Junction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development Central Nervous System Morphogenesis Nerve Growth Factor Production	Dystrophin-associated Glycoprotein Complex Sarcolemma Syntrophin Complex Muscle Contraction Muscle System Process Actin Binding Vinculin Binding Structural Molecule Activity Cytoskeleton Regulation Of Sodium Ion Transmembrane Transport System Process Regulation Of Sodium Ion Transport Protein-containing Complex Filopodium Nitric-oxide Synthase Binding Neuromuscular Junction PDZ Domain Binding Plasma Membrane Costamere Structural Constituent Of Cytoskeleton Regulation Of Monoatomic Ion Transmembrane Transport Synapse Filopodium Membrane Myosin Binding Regulation Of Transport Positive Regulation Of Endocytosis Anchoring Junction Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Monoatomic Ion Transport Cardiac Muscle Cell Action Potential Structural Constituent Of Muscle Calmodulin Binding Regulation Of Heart Contraction Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoplasm Postsynaptic Membrane Regulation Of Blood Circulation Lateral Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Postsynaptic Density Glutamatergic Synapse Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Neurofilament Cytoskeleton Positive Regulation Of Macropinocytosis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Actin Cytoskeleton Signaling Striated Muscle Contraction Cell Communication
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