FLT4 and SHC1

Number of citations of the paper that reports this interaction (PMID 9927207)
5

Data Source:
HPRD (in vitro, in vivo)

		FLT4	SHC1
Gene Name		fms-related tyrosine kinase 4	SHC (Src homology 2 domain containing) transforming protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Mitochondrial Matrix Cytosol Plasma Membrane Shc-EGFR Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Ephrin Receptor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling	MAPK Cascade Activation Of MAPK Activity Angiogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Ras Protein Signal Transduction Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Single Organismal Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Platelet Activation Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of DNA Replication Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	Signaling by GPCR Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) SHC1 events in ERBB2 signaling IRE1alpha activates chaperones Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling SHC-mediated signalling G-protein beta:gamma signalling SHC-related events triggered by IGF1R Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling SHC1 events in ERBB4 signaling Signalling to RAS Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Signalling to ERKs IGF1R signaling cascade XBP1(S) activates chaperone genes G beta:gamma signalling through PI3Kgamma Unfolded Protein Response (UPR) Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall SHC1 events in EGFR signaling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Constitutive Signaling by EGFRvIII SHC activation
Drugs		Sorafenib Sunitinib Pazopanib Axitinib Regorafenib
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		13 interactors: ATF7IP FIGF GRB2 IKBKG ITGA5 ITGB1 KDR NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC	134 interactors: ALK AP2A1 AP2A2 APP AXL BCL3 BCR C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FCGR2A FCGR3A FGFR1 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLSCR1 PPAP2B PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RET SH2B2 SHCBP1 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR VAV1 VAV3 ZAP70
Entrez ID		2324	6464
HPRD ID		00636	02780
Ensembl ID		ENSG00000037280	ENSG00000160691
Uniprot IDs		P35916	P29353
PDB IDs		4BSJ 4BSK	1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C
Enriched GO Terms of Interacting Partners?		Blood Vessel Morphogenesis Blood Coagulation Hemostasis Locomotion Blood Vessel Development Vasculature Development Cardiovascular System Development Angiogenesis Regulation Of Body Fluid Levels Wound Healing Anatomical Structure Formation Involved In Morphogenesis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Migration Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Cell Motility Positive Regulation Of Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Viral Process Regulation Of Phosphorus Metabolic Process Response To Growth Factor Positive Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Cell Activation Anatomical Structure Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Cell-substrate Adhesion Platelet Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Anoikis Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Leukocyte Migration Regulation Of Signal Transduction Regulation Of Anoikis Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Response To Organic Substance Signaling Peptidyl-tyrosine Phosphorylation Cell Communication Cellular Response To Organic Substance Regulation Of Signal Transduction Cellular Response To Stimulus Immune System Process Regulation Of Signaling Intracellular Signal Transduction Response To Stimulus Regulation Of Phosphorylation Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Protein Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Locomotion Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Innate Immune Response Positive Regulation Of Protein Metabolic Process Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Positive Regulation Of MAPK Cascade Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Difference) ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Intersection) ?