FLT4 and FIGF

Number of citations of the paper that reports this interaction (PMID 9435229)
143

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		FLT4	FIGF
Gene Name		fms-related tyrosine kinase 4	c-fos induced growth factor (vascular endothelial growth factor D)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding	Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Growth Factor Activity Chemoattractant Activity Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 3 Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling	Angiogenesis Platelet Degranulation Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Cell Differentiation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs		Sorafenib Sunitinib Pazopanib Axitinib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ATF7IP FIGF GRB2 IKBKG ITGA5 ITGB1 KDR NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC	3 interactors: FLT4 ITGA9 KDR
Entrez ID		2324	2277
HPRD ID		00636	02102
Ensembl ID		ENSG00000037280	ENSG00000165197
Uniprot IDs		P35916	O43915
PDB IDs		4BSJ 4BSK	2XV7
Enriched GO Terms of Interacting Partners?		Blood Vessel Morphogenesis Blood Coagulation Hemostasis Locomotion Blood Vessel Development Vasculature Development Cardiovascular System Development Angiogenesis Regulation Of Body Fluid Levels Wound Healing Anatomical Structure Formation Involved In Morphogenesis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Migration Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Cell Motility Positive Regulation Of Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Viral Process Regulation Of Phosphorus Metabolic Process Response To Growth Factor Positive Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Cell Activation Anatomical Structure Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Cell-substrate Adhesion Platelet Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Anoikis Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Leukocyte Migration Regulation Of Signal Transduction Regulation Of Anoikis Signal Transduction	Lymph Vessel Development Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Epithelial Cell Proliferation Regulation Of Blood Vessel Remodeling Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Morphogenesis Positive Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Positive Regulation Of Protein Kinase C Signaling Lymphangiogenesis Blood Vessel Development Surfactant Homeostasis Vasculature Development Lymph Vessel Morphogenesis Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Vasculogenesis Chemical Homeostasis Within A Tissue Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Vasculogenesis Regulation Of Cell Motility Regulation Of Protein Kinase C Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Migration Involved In Sprouting Angiogenesis
Tagcloud ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?