FLT4 and DUSP19

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		FLT4	DUSP19
Description		fms related receptor tyrosine kinase 4	dual specificity phosphatase 19
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Phosphatase Binding Protein Homodimerization Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity JUN Kinase Phosphatase Activity Hydrolase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade	MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade
Pathways		VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 Denibulin Linifanib IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Tivozanib Fostamatinib Selpercatinib
Diseases		Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Serum folate levels ( 29953918)
Interacting Genes		16 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD	19 interacting genes: ACTB ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2
Entrez ID		2324	142679
HPRD ID		00636	13254
Ensembl ID		ENSG00000037280	ENSG00000162999
Uniprot IDs		E9PD35 P35916	Q8WTR2
PDB IDs		4BSJ 4BSK	3S4E 4D3P 4D3Q 4D3R
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Angiogenesis Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Vascular Endothelial Growth Factor Signaling Pathway Receptor Internalization Integrin Alpha5-beta1 Complex Negative Regulation Of Anoikis Regulation Of Vasculature Development Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Positive Chemotaxis Regulation Of Anoikis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Integrin-mediated Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Mast Cell Chemotaxis Neurotrophin TRKA Receptor Binding Beta-2 Adrenergic Receptor Binding Positive Regulation Of Chemotaxis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Integrin Binding Response To Growth Factor Peptidyl-tyrosine Phosphorylation Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Migration Developmental Process	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Receptor Complex Nucleotide Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Signal Transduction Growth Factor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Coreceptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Signal Transduction Response To Growth Factor Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Axon Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Positive Regulation Of Phosphate Metabolic Process ERBB3:ERBB2 Complex ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade
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