FLT4 and VEGFC

Number of citations of the paper that reports this interaction (PMID 8700872)
52

Data Source:
HPRD (in vivo)

		FLT4	VEGFC
Gene Name		fms-related tyrosine kinase 4	vascular endothelial growth factor C
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding	Protein Binding Growth Factor Activity Chemoattractant Activity Vascular Endothelial Growth Factor Receptor 3 Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Platelet Degranulation Substrate-dependent Cell Migration Signal Transduction Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Platelet Activation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Response To Drug Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Positive Regulation Of Lymphangiogenesis
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs		Sorafenib Sunitinib Pazopanib Axitinib Regorafenib
Diseases
GWAS			HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		13 interactors: ATF7IP FIGF GRB2 IKBKG ITGA5 ITGB1 KDR NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC	2 interactors: FLT4 KDR
Entrez ID		2324	7424
HPRD ID		00636	03317
Ensembl ID		ENSG00000037280	ENSG00000150630
Uniprot IDs		P35916	P49767
PDB IDs		4BSJ 4BSK	2X1W 2X1X 4BSK
Enriched GO Terms of Interacting Partners?		Blood Vessel Morphogenesis Blood Coagulation Hemostasis Locomotion Blood Vessel Development Vasculature Development Cardiovascular System Development Angiogenesis Regulation Of Body Fluid Levels Wound Healing Anatomical Structure Formation Involved In Morphogenesis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Migration Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Cell Motility Positive Regulation Of Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Viral Process Regulation Of Phosphorus Metabolic Process Response To Growth Factor Positive Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Cell Activation Anatomical Structure Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Cell-substrate Adhesion Platelet Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Anoikis Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Leukocyte Migration Regulation Of Signal Transduction Regulation Of Anoikis Signal Transduction	Lymph Vessel Development Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Blood Vessel Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Blood Vessel Remodeling Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cell Motility Positive Regulation Of Protein Kinase C Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Lymphangiogenesis Positive Regulation Of Protein Phosphorylation Surfactant Homeostasis Lymph Vessel Morphogenesis Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Vasculogenesis Chemical Homeostasis Within A Tissue Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Vasculogenesis Cardiovascular System Development Regulation Of Protein Kinase C Signaling
Tagcloud ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vps13a wuzhishan wzsp zfpm2
Tagcloud (Difference) ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vps13a wuzhishan wzsp zfpm2
Tagcloud (Intersection) ?