FLT4 and SHC3

Number of citations of the paper that reports this interaction (PMID 9345034)
1

Data Source:
HPRD (in vitro)

		FLT4	SHC3
Gene Name		fms-related tyrosine kinase 4	SHC (Src homology 2 domain containing) transforming protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Cellular_component Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding	Signal Transducer Activity Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Central Nervous System Development Learning Or Memory Insulin Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Neurotrophin TRK Receptor Signaling Pathway
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade Signal attenuation Signalling to RAS Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-mediated signalling Signaling by Insulin receptor
Drugs		Sorafenib Sunitinib Pazopanib Axitinib Regorafenib
Diseases
GWAS			Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		13 interactors: ATF7IP FIGF GRB2 IKBKG ITGA5 ITGB1 KDR NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC	16 interactors: ALK APP ARHGAP32 AXL EGFR ERBB2 ERBB3 FLT4 GOLGA2 GRB2 KRT31 KRT40 NTRK1 NTRK2 RET SH3GL3
Entrez ID		2324	53358
HPRD ID		00636	12005
Ensembl ID		ENSG00000037280
Uniprot IDs		P35916	Q92529
PDB IDs		4BSJ 4BSK
Enriched GO Terms of Interacting Partners?		Blood Vessel Morphogenesis Blood Coagulation Hemostasis Locomotion Blood Vessel Development Vasculature Development Cardiovascular System Development Angiogenesis Regulation Of Body Fluid Levels Wound Healing Anatomical Structure Formation Involved In Morphogenesis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Migration Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Cell Motility Positive Regulation Of Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Viral Process Regulation Of Phosphorus Metabolic Process Response To Growth Factor Positive Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Cell Activation Anatomical Structure Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Cell-substrate Adhesion Platelet Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Anoikis Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Leukocyte Migration Regulation Of Signal Transduction Regulation Of Anoikis Signal Transduction	Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Peptidyl-amino Acid Modification Regulation Of Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Nervous System Development Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Phosphorylation Phosphatidylinositol-mediated Signaling Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Neuron Development Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Generation Of Neurons Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Signal Transduction System Development Locomotion Cell Development Positive Regulation Of Synaptic Transmission, Glutamatergic Developmental Process Cellular Response To Organic Substance Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cell Communication Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www
Tagcloud (Difference) ?		139x 200x 287x 900x actionable akt1 archival cdh1 cdkn2a constitutes ctdna ctnnb1 depths jak3 lobular massively mirrored mml3 mps nct01090960 nf1 pharmacodynamic posed posit read repertoire synchronous synonymous www
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