SYT11 and PLEKHO1

Data Source: HiPPIP (Novel)

		SYT11	PLEKHO1
Name		synaptotagmin 11	pleckstrin homology domain containing O1
Structure		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Vesicle Early Phagosome Cell Projection Neuron Projection Dendritic Spine Perikaryon Synapse Phagocytic Vesicle Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Inhibitory Synapse Exocytic Vesicle Dopaminergic Synapse Presynapse	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane
	Molecular Function	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Translation Initiation Factor Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Beta-tubulin Binding Calcium Ion Sensor Activity	Protein Binding
	Biological Process	Plasma Membrane Repair Negative Regulation Of Cytokine Production Vesicle Fusion Autophagy Learning Memory Response To Wounding Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Dopamine Secretion Negative Regulation Of Endocytosis Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Phagocytosis Establishment Of Vesicle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Defense Response To Bacterium Negative Regulation Of Secretion By Cell Negative Regulation Of Microglial Cell Activation Regulation Of Phagosome Maturation Positive Regulation Of Protein Localization To Phagocytic Vesicle Calcium Ion Regulated Lysosome Exocytosis	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	None
GWAS		Blood protein levels ( 30072576 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 28892062 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Parkinson's disease ( 25064009 21292315 ) Serum cancer antigen 15.3 levels ( 31666285 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Bipolar disorder ( 31043756 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )
Novel Interactors		1 novel interactors: PLEKHO1	7 novel interactors: ADAMTSL4 C1orf56 CDC42SE1 GOLPH3L RPRD2 SMG5 SYT11
Interacting Genes		6 interacting genes: APPBP2 GPR35 PRKN SGTA SGTB SYNCRIP	33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1
Entrez ID		23208	51177
HPRD ID		12289	12217
Ensembl ID		ENSG00000132718	ENSG00000023902
Uniprot IDs		Q9BT88	Q53GL0 Q5T4P9
PDB IDs		Not available	3AA1
GO Terms Enriched among Interactors		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Hsp70 Protein Binding Negative Regulation Of Response To Endoplasmic Reticulum Stress Membrane Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitochondrial Fusion Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Cellular Response To L-glutamine Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Protein Targeting To Membrane BAT3 Complex Binding MRNA Editing Complex GAIT Complex Muscle Cell Projection Membrane Cellular Localization Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neurotransmitter Uptake	Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response