CYFIP1 and MEOX1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		CYFIP1	MEOX1
Description		cytoplasmic FMR1 interacting protein 1	mesenchyme homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Focal Adhesion Lamellipodium SCAR Complex Cell Leading Edge Secretory Granule Lumen Specific Granule Lumen Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Tertiary Granule Lumen	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA 7-methylguanosine Cap Binding Actin Binding Protein Binding Translation Repressor Activity Small GTPase Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Morphogenesis Regulation Of Translation Nervous System Development Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Negative Regulation Of Translation Lamellipodium Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Neuron Projection Development Ruffle Organization Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Somite Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)	Fractures ( 30158200)
Interacting Genes		19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 EIF4E FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1	99 interacting genes: ACBD4 ACOT12 AIRIM ALOX5 ANAPC2 APP APPL1 ATG9A BANP BNIP2 BYSL C14orf119 C1orf50 CACNB3 CATSPERT CCDC102B CDC34 CIAO1 CIB3 CIMIP4 CKS1B CNOT11 CSNK2A1 CWF19L2 CYFIP1 DCX DNAAF19 DUSP3 EIF4A3 EIF4EBP1 EMD FMR1 GCC1 GEMIN2 GPANK1 GYS1 HMBOX1 HMGB3 HOMER3 HOXC8 HYCC2 INPP5J KANK2 KCTD7 L3MBTL2 LMNA MAPK9 MBD3 MCRS1 MEF2A MID1 MID2 MKRN3 MLX MORF4L1 MVP NAGK NDOR1 NEIL2 OSGIN1 PAGE3 PARVG PAX1 PAX3 PCP2 PDE4C PELI2 PIN1 PLCD4 PM20D2 POLR3GL PPM1F PRKAG1 PRKN QRICH1 RAD52 RANBP3 RBM41 RBM5 SDCBP SEC14L4 SOX10 SPAG8 SPIC SYT17 TCEANC TCP11L1 TRAPPC2L TRIM41 TRIML2 TRIP10 TXLNA TXNL4B UBE2R2 UBXN2B UBXN7 UNC45A ZCCHC10 ZNF410
Entrez ID		23191	4222
HPRD ID		05890	02537
Ensembl ID		ENSG00000273749	ENSG00000005102
Uniprot IDs		Q7L576	P50221
PDB IDs		3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Neuron Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Postsynapse Nuclear Speck MRNA Transport RNA Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Nucleobase-containing Compound Transport RNA Export From Nucleus Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytoplasmic Stress Granule RNA Binding Developmental Process Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Intracellular Signaling Cassette Nuclear Export Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Secretion Protein-containing Complex Binding Neuron Differentiation RNA Splicing Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Dendritic Spine Development Presynaptic Modulation Of Chemical Synaptic Transmission Cell Projection Organization Eukaryotic Initiation Factor 4G Binding Positive Regulation Of Intracellular Transport Of Viral Material Telomere Tethering At Nuclear Periphery Secretin Receptor Activity Pancreatic Epsilon Cell Differentiation Lamellipodium MRNA Processing Molecular Condensate Scaffold Activity Regulation Of Dendritic Spine Development Dendritic Filopodium Positive Regulation Of Neurogenesis Histone H3 Reader Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pancreatic D Cell Differentiation	Protein Binding Cytosol Nucleoplasm Cytoplasm Growth Cone Filopodium Spindle Pole Centrosome Translation Repressor Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Identical Protein Binding Perinuclear Region Of Cytoplasm Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Translation At Postsynapse
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