CYFIP1 and MYO16

Number of citations of the paper that reports this interaction (PubMedID 21946561)
80

Data Source:
BioGRID (pull down)

		CYFIP1	MYO16
Description		cytoplasmic FMR1 interacting protein 1	myosin XVI
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Focal Adhesion Lamellipodium SCAR Complex Cell Leading Edge Secretory Granule Lumen Specific Granule Lumen Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Tertiary Granule Lumen	Nucleoplasm Cytoplasm Plasma Membrane Myosin Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA 7-methylguanosine Cap Binding Actin Binding Protein Binding Translation Repressor Activity Small GTPase Binding Actin Filament Binding	Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding ATP Binding Protein Phosphatase Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Regulation Of Translation Nervous System Development Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Negative Regulation Of Translation Lamellipodium Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Neuron Projection Development Ruffle Organization Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Negative Regulation Of Cell Population Proliferation Cerebellum Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)	Alzheimer's disease ( 30636644) Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 22763476) Chronotype ( 30696823) Colorectal cancer ( 29228715) Dental caries ( 23064961) Eosinophil count ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Ferritin levels ( 33491795) Lung function (FEV1/FVC) ( 30804560) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Nose size ( 27182965) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Presence of antiphospholipid antibodies ( 23509613) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Seasonality ( 25562672) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 EIF4E FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1	6 interacting genes: CYFIP1 NCKAP1 NRXN1 PIK3R1 PPP1CA PPP1CC
Entrez ID		23191	23026
HPRD ID		05890	14795
Ensembl ID		ENSG00000273749	ENSG00000041515
Uniprot IDs		Q7L576	F8W883 Q9Y6X6
PDB IDs		3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Neuron Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Postsynapse Nuclear Speck MRNA Transport RNA Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Nucleobase-containing Compound Transport RNA Export From Nucleus Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytoplasmic Stress Granule RNA Binding Developmental Process Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Intracellular Signaling Cassette Nuclear Export Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Secretion Protein-containing Complex Binding Neuron Differentiation RNA Splicing Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Dendritic Spine Development Presynaptic Modulation Of Chemical Synaptic Transmission Cell Projection Organization Eukaryotic Initiation Factor 4G Binding Positive Regulation Of Intracellular Transport Of Viral Material Telomere Tethering At Nuclear Periphery Secretin Receptor Activity Pancreatic Epsilon Cell Differentiation Lamellipodium MRNA Processing Molecular Condensate Scaffold Activity Regulation Of Dendritic Spine Development Dendritic Filopodium Positive Regulation Of Neurogenesis Histone H3 Reader Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pancreatic D Cell Differentiation	Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Organization Postsynapse PTW/PP1 Phosphatase Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Actin Nucleation Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Rac Protein Signal Transduction Photoperiodism Entrainment Of Circadian Clock Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Protein Stabilization Presynapse Lamellipodium Assembly Regulation Of Actin Nucleation Regulation Of Actin Filament Organization Lamellipodium Organization Regulation Of Filopodium Assembly Intracellular Signaling Cassette Response To Light Stimulus Glycogen Metabolic Process Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Stability Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Phosphatase Activity Polysaccharide Metabolic Process Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Focal Adhesion Positive Regulation Of Protein Localization To Membrane Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity
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