CYFIP1 and FMR1

Number of citations of the paper that reports this interaction (PMID 11438699)
59

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CYFIP1	FMR1
Gene Name		cytoplasmic FMR1 interacting protein 1	fragile X mental retardation 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Nucleolus Cytoplasm MRNA Cap Binding Complex Microtubule Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome Dendritic Spine Dendritic Shaft Cell Body Synapse Neuronal Ribonucleoprotein Granule
	Molecular Function	Protein Binding Protein Complex Binding Rac GTPase Binding Actin Filament Binding	RNA Binding MRNA Binding Protein Binding Microtubule Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Cell Shape Rac Protein Signal Transduction Lamellipodium Assembly Ruffle Organization Axon Extension Cognition Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Central Nervous System Development Negative Regulation Of Translation Negative Regulation Of Translational Initiation MRNA Transport
Pathways
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956)
Protein-Protein Interactions		15 interactors: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1	15 interactors: CYFIP1 CYFIP2 FSD2 FXR1 FXR2 INCA1 MEOX1 NCL NUFIP1 NUFIP2 RANBP9 SPAG5 STAU1 UBE2I YBX1
Entrez ID		23191	2332
HPRD ID		05890	02398
Ensembl ID		ENSG00000068793	ENSG00000102081
Uniprot IDs		Q7L576	G3V0J0 G8JL90 G8JLE9 Q06787 Q8IXW7 R9WQY1
PDB IDs		3P8C	2BKD 2FMR 2LA5 2QND
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Actin Filament Polymerization Pancreatic Epsilon Cell Differentiation Negative Regulation Of Thymidylate Synthase Biosynthetic Process Pancreatic D Cell Differentiation Actin Filament Organization Response To Light Stimulus System Development Actin Polymerization Or Depolymerization Negative Regulation Of Translation Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Skeletal Muscle Fiber Adaptation Protein Polymerization Engulfment Of Apoptotic Cell Response To Radiation Tissue Development Multicellular Organismal Development Mast Cell Chemotaxis Sclerotome Development Regulation Of Cell Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Response To External Stimulus Energy Reserve Metabolic Process Cell Cycle Arrest Positive Regulation Of DNA Metabolic Process Cytoskeleton Organization Somite Specification	Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Translation Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation By Virus Of Viral Protein Levels In Host Cell Box C/D SnoRNP Assembly Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Process Sclerotome Development CRD-mediated MRNA Stabilization Somite Specification Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase I Promoter Intracellular MRNA Localization Chromosome Segregation Positive Regulation Of Macromolecule Biosynthetic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Gene Expression Regulation Of Gene Expression
Tagcloud ?		4e bdnf boncat cap depends eif4e eif4g encoded find fmrp gtp implicate latter mek mnk1 mnks neurotransmission neurotrophic obscure overlap partner phosphorylates plasticity repressor silac subset synthesis translational whose	17beta cav1 caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		4e bdnf boncat cap depends eif4e eif4g encoded find gtp implicate latter mek mnk1 mnks neurotransmission neurotrophic obscure overlap partner phosphorylates repressor silac subset synthesis translational whose	17beta cav1 caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fragile fxs glua1 inherited interacted ko potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Intersection) ?		fmrp plasticity