RFC3 and ANKRD40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RFC3	ANKRD40
Description		replication factor C subunit 3	ankyrin repeat domain 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Protein-containing Complex	Cellular_component
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity	Molecular_function Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity	Biological_process
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)
Interacting Genes		14 interacting genes: ANKRD40 ARFGAP1 CEBPA CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4	5 interacting genes: FXR1 PIN1 RAD23A RFC3 SDCBP
Entrez ID		5983	91369
HPRD ID		02676	17502
Ensembl ID		ENSG00000133119	ENSG00000154945
Uniprot IDs		P40938	A8IK34 Q6AI12
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process DNA Replication DNA Replication Factor C Complex Ctf18 RFC-like Complex Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Negative Regulation Of Cell Cycle Nucleoplasm Identical Protein Binding DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Dendritic Spine Organization Response To Dexamethasone Regulation Of DNA Metabolic Process Neuron Projection Organization Postsynapse Organization DNA Repair Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding PCNA Complex Replisome Negative Regulation Of Synaptic Vesicle Clustering Rad17 RFC-like Complex DNA-templated DNA Replication Regulation Of Catalytic Activity Cellular Response To Stress Animal Organ Regeneration Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Clamp Unloader Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Catalytic Activity	Positive Regulation Of Protein Metabolic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Positive Regulation Of Metabolic Process Protein Targeting Positive Regulation Of Phosphate Metabolic Process Ubiquitin Ligase Activator Activity Regulation Of Primary Metabolic Process Phosphoserine Residue Binding Positive Regulation Of Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Protein Peptidyl-prolyl Isomerization Regulation Of Macromolecule Metabolic Process Phosphothreonine Residue Binding Cis-trans Isomerase Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Cycle DNA Clamp Loader Activity DNA Replication Factor C Complex Ctf18 RFC-like Complex Positive Regulation Of DNA-directed DNA Polymerase Activity Substrate-dependent Cell Migration, Cell Extension Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Regulation Of Extracellular Exosome Assembly Syndecan Binding RNA Strand Annealing Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Nuclear Pore Localization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Membraneless Organelle Nuclear Pore Complex Assembly Regulation Of Cellular Response To Growth Factor Stimulus Protein Heterodimerization Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Catabolic Process DNA Strand Elongation Involved In DNA Replication Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Costamere Ribonucleoprotein Granule Nuclear Pore Organization Regulation Of Metabolic Process Proteasome Binding
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