CASR and STAMBP

Number of citations of the paper that reports this interaction (PubMedID 16854379)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CASR	STAMBP
Description		calcium sensing receptor	STAM binding protein
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Protein Domain Specific Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Ossification Response To Ischemia Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Metal Ion Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Response To Calcium Ion Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Regulation Of Presynaptic Membrane Potential Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Peptide Chloride Transmembrane Transport	Mitotic Cytokinesis Proteolysis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Deubiquitination Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process
Pathways		G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Metalloprotease DUBs
Drugs		Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases		Bartter syndrome
GWAS		Calcium levels ( 20661308 20705733 24068962 29403010 25886283 25972035) Cardiac Troponin-T levels ( 23247143) Chronic widespread musculoskeletal pain ( 33331911) Clinical laboratory measurements ( 27897004) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 30718926 32499647)	Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL	51 interacting genes: ALAS1 AMN APOBEC3A ATG14 BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 DSCR9 EGFR EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 MLKL NLRP7 NTPCR PJA1 RBM11 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28 VHL
Entrez ID		846	10617
HPRD ID		03122	05877
Ensembl ID		ENSG00000036828	ENSG00000124356
Uniprot IDs		P41180	A0A140VK54 A0A804HIF8 A0A804HII8 A0A804HJ64 O95630
PDB IDs		5FBH 5FBK 5K5S 5K5T 7DTT 7DTU 7DTV 7DTW 7E6T 7E6U 7M3E 7M3F 7M3G 7M3J 7SIL 7SIM 7SIN 8SZF 8SZG 8SZH 8SZI 8WPG 8WPU 9ASB 9AVG 9AVL 9AXF 9AYF 9C1P 9C2F 9J7I	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?		Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Secretion By Cell Regulation Of Secretion Protein Kinase C Signaling Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Exocytosis Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Synaptic Signaling Via Neuropeptide Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Transcription Regulator Activator Activity Mitotic Nuclear Membrane Disassembly Regulation Of Programmed Cell Death Positive Regulation Of Insulin Secretion Regulation Of Protein Secretion Regulation Of Neural Precursor Cell Proliferation Regulation Of Signal Transduction Regulation Of Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Regulation Of Cell Population Proliferation Positive Regulation Of Peptide Secretion Regulation Of Blood Vessel Endothelial Cell Migration Calyx Of Held Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Hypoxia Glandular Epithelial Cell Differentiation Cellular Response To Decreased Oxygen Levels Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Enzyme Binding Plasma Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Biomineral Tissue Development Presynaptic Cytosol Cellular Response To Oxygen Levels	ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Organization Multivesicular Body Assembly Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Late Endosome To Vacuole Transport Lysosomal Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Autophagosome Membrane Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Mitotic Spindle Organization Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Endosome Organization Regulation Of Spindle Assembly Autophagy Cytokinetic Process Protein-containing Complex Disassembly Endosomal Transport Multivesicular Body Mitotic Metaphase Chromosome Alignment Biological Process Involved In Interaction With Host Nuclear Membrane Organization Vacuolar Transport Vacuole Organization Metaphase Chromosome Alignment Membrane Assembly Endosome Macroautophagy Regulation Of Microtubule Cytoskeleton Organization Chromosome Localization Lysosomal Transport Regulation Of Centrosome Duplication Nuclear Pore Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Organization
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