CASR and PI4K2B

Number of citations of the paper that reports this interaction (PMID 11907035)
9

Data Source:
HPRD (in vivo)

		CASR	PI4K2B
Gene Name		calcium-sensing receptor	phosphatidylinositol 4-kinase type 2 beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G-protein Coupled Receptor Activity Protein Binding	1-phosphatidylinositol 4-kinase Activity ATP Binding
	Biological Process	Ossification Detection Of Calcium Ion Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Chemosensory Behavior Metabolic Process Anatomical Structure Morphogenesis Calcium Ion Import	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the ER membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs		Cinacalcet
Diseases
GWAS		Calcium levels ( 20661308 20705733) Cardiac Troponin-T levels ( 23247143) Phosphorus levels ( 20558539)
Protein-Protein Interactions		7 interactors: FLNA PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP	4 interactors: AKT1 CASR CD247 MAPK14
Entrez ID		846	55300
HPRD ID		03122	15132
Ensembl ID		ENSG00000036828	ENSG00000038210
Uniprot IDs		P41180	G5E9Z4 Q8TCG2
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3-T6 Phosphorylation Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Glucose Transport Regulation Of Body Fluid Levels Wound Healing Mitotic Cell Cycle Process Cell Activation Response To Wounding Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Negative Regulation Of Insulin Receptor Signaling Pathway Histone Phosphorylation Nuclear Envelope Disassembly Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Cell Cycle Process Positive Regulation Of Phospholipase C Activity Negative Regulation Of Transport Regulation Of Insulin Receptor Signaling Pathway Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Mismatch Repair Positive Regulation Of Dense Core Granule Biogenesis Cell Cycle Regulation Of Glucose Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Protein Catabolic Process Nucleus Organization Positive Regulation Of Angiogenesis Regulation Of Mismatch Repair Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Response To Carbohydrate Cellular Response To Fibroblast Growth Factor Stimulus	Positive Regulation Of Vasoconstriction Immune Response-regulating Signaling Pathway Positive Regulation Of Fat Cell Differentiation Regulation Of Vasoconstriction Response To Peptide Cellular Response To Growth Factor Stimulus T Cell Costimulation Response To Growth Factor Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Establishment Of Protein Localization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Cellular Response To Oxygen Levels Peptidyl-serine Phosphorylation Stress-activated MAPK Cascade Regulation Of Protein Localization Stress-activated Protein Kinase Signaling Cascade Innate Immune Response Glycogen Cell Differentiation Involved In Embryonic Placenta Development P38MAPK Cascade Response To Organonitrogen Compound Regulation Of Fat Cell Differentiation Regulation Of Immune Response Glucose Metabolic Process Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Metabolic Process Apoptotic Process Programmed Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Cell Death Death Response To Abiotic Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Ion Transport Glucose Homeostasis Hexose Metabolic Process Positive Regulation Of T Cell Activation Response To Stress Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway MAPK Cascade Striated Muscle Cell Differentiation Positive Regulation Of Intracellular Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation
Tagcloud ?		ascending balancing ca2 cations collecting concentrating divalent excretion furnish glands henle homeostatic hypercalcemia implicating insipidus integrating losses messenger mg2 mineral minimizes parathyroid phospholipases polyuria reabsorbtion reabsorption responds stone thyroidal
Tagcloud (Difference) ?		ascending balancing ca2 cations collecting concentrating divalent excretion furnish glands henle homeostatic hypercalcemia implicating insipidus integrating losses messenger mg2 mineral minimizes parathyroid phospholipases polyuria reabsorbtion reabsorption responds stone thyroidal
Tagcloud (Intersection) ?