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DCUN1D4 and VAV2
Number of citations of the paper that reports this interaction (PMID
18654987
)
7
Data Source:
BioGRID
(two hybrid)
DCUN1D4
VAV2
Gene Name
DCN1, defective in cullin neddylation 1, domain containing 4
vav 2 guanine nucleotide exchange factor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Molecular Function
Molecular_function
Protein Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
Metal Ion Binding
Biological Process
Biological_process
Angiogenesis
Signal Transduction
Small GTPase Mediated Signal Transduction
Axon Guidance
Blood Coagulation
Regulation Of Gene Expression
Cell Migration
Lamellipodium Assembly
Platelet Activation
Regulation Of Blood Coagulation
Positive Regulation Of Rho GTPase Activity
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Axon guidance
L1CAM interactions
FCERI mediated MAPK activation
VEGFA-VEGFR2 Pathway
Rho GTPase cycle
DAP12 signaling
EPH-ephrin mediated repulsion of cells
VEGFR2 mediated vascular permeability
EPH-Ephrin signaling
G alpha (12/13) signalling events
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Signalling by NGF
DAP12 interactions
Signal transduction by L1
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
GPCR downstream signaling
Signaling by VEGF
NRAGE signals death through JNK
Signaling by Rho GTPases
GPVI-mediated activation cascade
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Multiple sclerosis (
20598377
)
vWF and FVIII levels (
21810271
)
Protein-Protein Interactions
8 interactors:
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
UBE2M
VAV2
62 interactors:
ARIH1
BIRC6
BOD1L1
BRDT
BZW1
CBL
CBLB
CCNO
CCT2
CCT3
CD19
CD44
CEP170
CHMP3
CRCP
DCUN1D4
DNAJC21
EGFR
EIF4G3
EPHB2
ERBB2
ERBB3
FNTA
FUCA1
FYN
GAPVD1
GRB2
HNRNPF
HSPH1
IPO4
MARCH7
MED21
MRGBP
NCKAP5
NEK3
PHF10
PNMA1
POGZ
PPM1B
PRLR
RAC1
RAD23A
RBBP6
RHOA
RHOG
SERBP1
SF3A3
SH3BP2
SNW1
SOCS1
SRPK2
SRRT
ST13
STK24
SYK
TARBP2
TCP11
TOM1L1
TTN
UBE4B
USP38
VCPIP1
Entrez ID
23142
7410
HPRD ID
13791
02694
Ensembl ID
ENSG00000109184
ENSG00000160293
Uniprot IDs
B4DH25
B4DH26
Q92564
P52735
PDB IDs
2DLZ
2DM1
2LNW
2LNX
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Apoptotic Signaling Pathway
Cell Cycle Arrest
G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cellular Macromolecule Catabolic Process
Regulation Of Cell Cycle
Apoptotic Process
Negative Regulation Of Cell Cycle
Programmed Cell Death
Cell Death
Death
Protein Monoubiquitination
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Cell Cycle
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Proteolysis
Catabolic Process
Intracellular Signal Transduction
Cellular Protein Modification Process
Positive Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Viral Process
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Cellular Response To Stimulus
Negative Regulation Of Cell Proliferation
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Proliferation
Cellular Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Cell Cycle
Signal Transduction
Response To Stimulus
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Response To Fibroblast Growth Factor
Phosphatidylinositol-mediated Signaling
Cellular Response To Organic Substance
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Response To Organic Substance
Peptidyl-tyrosine Phosphorylation
Fc Receptor Signaling Pathway
Platelet Activation
Innate Immune Response
Regulation Of Cellular Protein Metabolic Process
Cellular Protein Modification Process
Cellular Metabolic Process
Protein Metabolic Process
Positive Regulation Of Viral Process
Regulation Of Body Fluid Levels
Wound Healing
Immune Response
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Axon Guidance
Cell Activation
Regulation Of Signal Transduction
Response To Wounding
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of T Cell Activation
Viral Process
Positive Regulation Of Signal Transduction
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Hemostasis
Protein Ubiquitination
Regulation Of Immune System Process
Signal Transduction
Regulation Of Intracellular Signal Transduction
Chemotaxis
Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?