DCUN1D4 and UBE2M

Number of citations of the paper that reports this interaction (PMID 23201271)
5

Data Source:
BioGRID (pull down)

		DCUN1D4	UBE2M
Gene Name		DCN1, defective in cullin neddylation 1, domain containing 4	ubiquitin-conjugating enzyme E2M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ribosomal S6-glutamic Acid Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Biological_process	Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 UBE2M VAV2	24 interactors: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL3 CUL7 DCUN1D3 DCUN1D4 MARCH7 MDM2 NAE1 NEDD4 NEDD8 PARK2 PINK1 RBX1 RNF111 RNF7 TP53 UBA3 UBC
Entrez ID		23142	9040
HPRD ID		13791	04414
Ensembl ID		ENSG00000109184	ENSG00000130725
Uniprot IDs		B4DH25 B4DH26 Q92564	P61081
PDB IDs			1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Apoptotic Signaling Pathway Cell Cycle Arrest G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Macromolecule Catabolic Process Regulation Of Cell Cycle Apoptotic Process Negative Regulation Of Cell Cycle Programmed Cell Death Cell Death Death Protein Monoubiquitination Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Proteolysis Catabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Cell Cycle Process Viral Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Proliferation Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Signal Transduction Response To Stimulus Regulation Of Protein Catabolic Process Protein Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Neddylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hypoxia Regulation Of Mitochondrion Degradation Cellular Response To Decreased Oxygen Levels Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cellular Response To Oxygen Levels Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Catabolic Process Notch Signaling Pathway Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Viral Process Protein Polyubiquitination Negative Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Apoptotic Process Cellular Response To Toxic Substance Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process Signaling Mitotic Cell Cycle Process Response To Oxidative Stress
Tagcloud ?			acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Difference) ?			acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Intersection) ?