DCUN1D4 and CEP135

		DCUN1D4	CEP135
Description		defective in cullin neddylation 1 domain containing 4	centrosomal protein 135
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Neddylation Positive Regulation Of Protein Neddylation	Centriole Replication Centriole-centriole Cohesion Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways		Neddylation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)	Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2	2 interacting genes: PIBF1 SMAD9
Entrez ID		23142	9662
HPRD ID		13791	11097
Ensembl ID		ENSG00000109184	ENSG00000174799
Uniprot IDs		B4DH26 Q92564	Q66GS9
PDB IDs		5V89	5FCN 5NG4
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Protein Ubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Modification Process Cul4A-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Proteasomal Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Cul4-RING E3 Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Interferon-mediated Signaling Pathway Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Macromolecule Catabolic Process Regulation Of Cell Cycle Phase Transition Trophectodermal Cellular Morphogenesis Liver Morphogenesis NEDD8 Conjugating Enzyme Activity SCF Complex Assembly Cellular Response To Light Stimulus Regulation Of Mitotic Cell Cycle Proteolysis Ribosome Biogenesis Regulation Protein Catabolic Process At Postsynapse Cytosol POZ Domain Binding Response To UV Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA-binding Transcription Factor Activity Transcription Regulator Complex Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Insulin Secretion Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Amniotic Stem Cell Differentiation Regulation Of Peptide Hormone Secretion Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Cortisol Biosynthetic Process Regulation Of Ketone Metabolic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Mesenchymal Stem Cell Differentiation Protein Modification Process CLOCK-BMAL Transcription Complex Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Negative Regulation Of Prostaglandin Biosynthetic Process Activation Of Janus Kinase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Adult Feeding Behavior Righting Reflex Behavioral Response To Ethanol Positive Regulation Of Metabolic Process Regulation Of Hormone Secretion Cellular Response To Electrical Stimulus Regulation Of Protein Secretion Regulation Of Glucocorticoid Metabolic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cardiac Muscle Cell Myoblast Differentiation Regulation Of Prostaglandin Biosynthetic Process Host-mediated Suppression Of Viral Transcription Cardioblast Differentiation Chromatoid Body
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