SPG20 and ZFYVE9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SPG20	ZFYVE9
Gene Name		spastic paraplegia 20 (Troyer syndrome)	zinc finger, FYVE domain containing 9
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Particle Plasma Membrane Midbody Synapse	Early Endosome Early Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding 1-phosphatidylinositol Binding Serine-type Peptidase Activity Metal Ion Binding
	Biological Process	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Particle Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development	Proteolysis Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP EPS15 ITCH PLIN3 SMURF1 SMURF2 TUBA1A WWP2 ZFYVE9	38 interactors: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBB2IP ETS2 FAM46A FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPG20 ST7 SUMF2 SUPT5H SVEP1 TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		23111	9372
HPRD ID		06170	04782
Ensembl ID		ENSG00000133104	ENSG00000157077
Uniprot IDs		Q8N0X7	O95405
PDB IDs		2DL1	1DEV 1MK2 4BKW
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Signaling Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Protein Ubiquitination Response To Transforming Growth Factor Beta Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K63-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Intracellular Transport Proteolysis Entry Into Host Cell Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Complex Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway BMP Signaling Pathway Establishment Of Localization In Cell Regulation Of ERBB Signaling Pathway Interaction With Host Synaptic Growth At Neuromuscular Junction Protein Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Localization Cellular Response To Growth Factor Stimulus Collateral Sprouting In Absence Of Injury Response To Growth Factor Notch Signaling Pathway Cytoskeleton-dependent Intracellular Transport Vesicle-mediated Transport Cellular Macromolecular Complex Assembly Endocytosis	Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Common-partner SMAD Protein Phosphorylation Cell Cycle Trachea Formation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Embryonic Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Embryonic Cranial Skeleton Morphogenesis Cellular Response To Organic Substance Response To Organic Substance Photoperiodism Entrainment Of Circadian Clock Embryonic Skeletal System Development Lens Development In Camera-type Eye Cell Cycle Process Regulation Of Growth Signal Transduction Trachea Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Embryonic Foregut Morphogenesis Regulation Of Gene Expression Foregut Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Lung Development Negative Regulation Of Growth Negative Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Respiratory Tube Development Glycogen Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Skeletal System Morphogenesis Tube Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Death
Tagcloud ?		adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Difference) ?		adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Intersection) ?