SPG20 and PLIN3

Number of citations of the paper that reports this interaction (PMID 19307600)
24

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SPG20	PLIN3
Gene Name		spastic paraplegia 20 (Troyer syndrome)	perilipin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Particle Plasma Membrane Midbody Synapse	Cytoplasm Endosome Golgi Apparatus Lipid Particle Endosome Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Particle Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development	Vesicle-mediated Transport
Pathways
Drugs			Idursulfase Galsulfase
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP EPS15 ITCH PLIN3 SMURF1 SMURF2 TUBA1A WWP2 ZFYVE9	9 interactors: APP CMTM5 IGF2R M6PR MAX RAB9A SMAD2 SPG20 TBPL1
Entrez ID		23111	10226
HPRD ID		06170	04080
Ensembl ID		ENSG00000133104	ENSG00000105355
Uniprot IDs		Q8N0X7	O60664
PDB IDs		2DL1
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Signaling Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Protein Ubiquitination Response To Transforming Growth Factor Beta Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K63-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Intracellular Transport Proteolysis Entry Into Host Cell Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Complex Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway BMP Signaling Pathway Establishment Of Localization In Cell Regulation Of ERBB Signaling Pathway Interaction With Host Synaptic Growth At Neuromuscular Junction Protein Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Localization Cellular Response To Growth Factor Stimulus Collateral Sprouting In Absence Of Injury Response To Growth Factor Notch Signaling Pathway Cytoskeleton-dependent Intracellular Transport Vesicle-mediated Transport Cellular Macromolecular Complex Assembly Endocytosis	Negative Regulation Of Cell Differentiation Neuron Apoptotic Process Neuron Death Negative Regulation Of Collateral Sprouting In Absence Of Injury Mannose Transport Regulation Of BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Synaptic Growth At Neuromuscular Junction Neuromuscular Process Collateral Sprouting In Absence Of Injury Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Post-embryonic Development Vesicle-mediated Transport DTTP Biosynthetic Process Endocytosis Regulation Of Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Process Abscission Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Mesoderm Development Primary MiRNA Processing Negative Regulation Of Neuron Differentiation Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Organ Development Endosomal Transport Sexual Reproduction Positive Regulation Of Activin Receptor Signaling Pathway DNA-templated Transcription, Initiation Regulation Of Cell Development Transcription From RNA Polymerase II Promoter Neuron Remodeling Anatomical Structure Development Cellular Component Assembly Regulation Of Binding Establishment Of Localization In Cell SMAD Protein Complex Assembly Developmental Growth Deoxyribonucleotide Biosynthetic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Paraxial Mesoderm Morphogenesis Acrosome Assembly Lipid Particle Organization
Tagcloud ?		adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole
Tagcloud (Difference) ?		adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole
Tagcloud (Intersection) ?