SPART and YOD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPART	YOD1
Description		spartin	YOD1 deubiquitinase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse	Cytoplasm Cytosol
	Molecular Function	Protein Binding Lipid Binding Ubiquitin Protein Ligase Binding	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Lipid Catabolic Process BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Collateral Sprouting In Absence Of Injury Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development Lipophagy Midbody Abscission Regulation Of Biological Quality	Proteolysis Response To Unfolded Protein Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways			Ovarian tumor domain proteases
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Systolic blood pressure ( 28234671)
Interacting Genes		21 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9	30 interacting genes: ATG14 BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 ZFP57
Entrez ID		23111	55432
HPRD ID		06170	10312
Ensembl ID		ENSG00000133104	ENSG00000180667
Uniprot IDs		A0A024RDV9 Q8N0X7	Q5VVQ6
PDB IDs		2DL1 4U7I	4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?		Cysteine-type Deubiquitinase Activity Protein K48-linked Deubiquitination Early Endosome Membrane Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Cytosol K48-linked Deubiquitinase Activity Endosome Early Endosome Deubiquitinase Activity Protein K63-linked Deubiquitination Proteolysis Protein Modification Process Cytoplasm Endocytosis Peptidase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization Import Into Cell Protein Ubiquitination Response To Mechanical Stimulus Negative Regulation Of Leukocyte Activation Regulation Of Immune Response Neuromuscular Junction Negative Regulation Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cell Activation Protein Modification By Small Protein Conjugation K63-linked Deubiquitinase Activity Regulation Of Notch Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ubiquitin Binding Regulation Of Signaling Ubiquitin Ligase Complex Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Vesicle-mediated Transport Symbiont Entry Into Host Cell Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Transporter Activity Regulation Of Signal Transduction	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein-containing Complex Protein K48-linked Ubiquitination Zinc Ion Binding Cytoplasm Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coactivator Activity Identical Protein Binding Proteolysis Proteolysis Involved In Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Signal Transduction Nucleus Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Nuclear Body Positive Regulation Of Protein Modification Process Regulation Of Defense Response Transferase Activity Negative Regulation Of Necroptotic Process Response To Other Organism Regulation Of RIG-I Signaling Pathway Negative Regulation Of Programmed Necrotic Cell Death Protein Catabolic Process Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process
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