SPG20 and ITCH

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		SPG20	ITCH
Gene Name		spastic paraplegia 20 (Troyer syndrome)	itchy E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Particle Plasma Membrane Midbody Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Ribonucleoprotein Complex Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Particle Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development	Regulation Of Cell Growth Positive Regulation Of T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Inflammatory Response Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOD1/2 Signaling Pathway Signaling by NOTCH1 Hedgehog 'on' state Signaling by NOTCH1 in Cancer Class I MHC mediated antigen processing & presentation FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Downregulation of ERBB4 signaling Signaling by NOTCH Signaling by ERBB4 Activated NOTCH1 Transmits Signal to the Nucleus RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by Hedgehog Degradation of GLI1 by the proteasome Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP EPS15 ITCH PLIN3 SMURF1 SMURF2 TUBA1A WWP2 ZFYVE9	80 interactors: ARID1A ARRB2 ARRDC1 ARRDC3 ATN1 BECN1 CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L DVL2 ERBB4 EWSR1 FYN GNAI2 HNRNPL HNRNPUL1 JUN LAPTM5 LATS1 LITAF MAP2K4 MAPK8 MLANA N4BP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SNX9 SPG20 STAM2 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 URI1 WBP2
Entrez ID		23111	83737
HPRD ID		06170	07565
Ensembl ID		ENSG00000133104	ENSG00000078747
Uniprot IDs		Q8N0X7	Q96J02
PDB IDs		2DL1	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Signaling Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Protein Ubiquitination Response To Transforming Growth Factor Beta Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K63-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Intracellular Transport Proteolysis Entry Into Host Cell Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Complex Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway BMP Signaling Pathway Establishment Of Localization In Cell Regulation Of ERBB Signaling Pathway Interaction With Host Synaptic Growth At Neuromuscular Junction Protein Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Localization Cellular Response To Growth Factor Stimulus Collateral Sprouting In Absence Of Injury Response To Growth Factor Notch Signaling Pathway Cytoskeleton-dependent Intracellular Transport Vesicle-mediated Transport Cellular Macromolecular Complex Assembly Endocytosis	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Protein Polyubiquitination Regulation Of Signaling Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nucleosome Disassembly TRIF-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Protein Catabolic Process Regulation Of Cellular Component Organization DNA-templated Transcription, Initiation Cell Death Death MRNA Splicing, Via Spliceosome
Tagcloud ?		adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
Tagcloud (Difference) ?		adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
Tagcloud (Intersection) ?