MYCBP2 and FBXL3

		MYCBP2	FBXL3
Description		MYC binding protein 2	F-box and leucine rich repeat protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Nuclear Body SCF Ubiquitin Ligase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process
Pathways			Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Chronotype ( 30696823) Metabolite levels ( 23823483) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	7 interacting genes: CDC34 CEP57 CRY2 MSRA PICK1 SKP1 UBE2D2
Entrez ID		23077	26224
HPRD ID		10104	05737
Ensembl ID		ENSG00000005810	ENSG00000005812
Uniprot IDs		O75592	Q9UKT7
PDB IDs		5O6C 6T7F	4I6J
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Cytosol Protein Modification By Small Protein Conjugation Post-translational Protein Modification Circadian Regulation Of Gene Expression Photoreactive Repair L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Axon Development Protein Metabolic Process Macromolecule Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Cry-Per Complex F-box Domain Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Glucocorticoid Secretion Circadian Rhythm Cul7-RING Ubiquitin Ligase Complex Membrane Curvature Sensor Activity Regulation Of Sodium-dependent Phosphate Transport Response To Blue Light Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Repair Branchiomotor Neuron Axon Guidance Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of Actin Nucleation Regulation Of Phosphate Transport Pyrimidine Dimer Repair Photoreceptor Activity Protein Domain Specific Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Nucleus Negative Regulation Of Circadian Rhythm Ubiquitin Ligase Activator Activity Neuronal Ion Channel Clustering Dendritic Spine Maintenance Regulation Of Axon Guidance Ubiquitin-protein Transferase Activity Rhythmic Process
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