FBXL3

Description		F-box and leucine rich repeat protein 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Nuclear Body SCF Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Metabolite levels ( 23823483) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Novel Interacting Genes		1 novel interacting genes: MYCBP2
Interacting Genes		7 interacting genes: CDC34 CEP57 CRY2 MSRA PICK1 SKP1 UBE2D2
Entrez ID		26224
HPRD ID		05737
Ensembl ID		ENSG00000005812
Uniprot IDs		Q9UKT7
PDB IDs		4I6J
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Cytosol Protein Modification By Small Protein Conjugation Post-translational Protein Modification Circadian Regulation Of Gene Expression Photoreactive Repair L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Axon Development Protein Metabolic Process Macromolecule Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Cry-Per Complex F-box Domain Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Glucocorticoid Secretion Circadian Rhythm Cul7-RING Ubiquitin Ligase Complex Membrane Curvature Sensor Activity Regulation Of Sodium-dependent Phosphate Transport Response To Blue Light Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Repair Branchiomotor Neuron Axon Guidance Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of Actin Nucleation Regulation Of Phosphate Transport Pyrimidine Dimer Repair Photoreceptor Activity Protein Domain Specific Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Nucleus Negative Regulation Of Circadian Rhythm Ubiquitin Ligase Activator Activity Neuronal Ion Channel Clustering Dendritic Spine Maintenance Regulation Of Axon Guidance Ubiquitin-protein Transferase Activity Rhythmic Process
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