FBXL3 and CDC34

Number of citations of the paper that reports this interaction (PubMedID 10531035)
0

Data Source:
BioGRID (enzymatic study)

		FBXL3	CDC34
Description		F-box and leucine rich repeat protein 3	cell division cycle 34, ubiquitin conjugating enzyme
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Nuclear Body SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins	Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronotype ( 30696823) Metabolite levels ( 23823483) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		7 interacting genes: CDC34 CEP57 CRY2 MSRA PICK1 SKP1 UBE2D2	60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1
Entrez ID		26224	997
HPRD ID		05737	00306
Ensembl ID		ENSG00000005812	ENSG00000099804
Uniprot IDs		Q9UKT7	P49427
PDB IDs		4I6J	2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Cytosol Protein Modification By Small Protein Conjugation Post-translational Protein Modification Circadian Regulation Of Gene Expression Photoreactive Repair L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Axon Development Protein Metabolic Process Macromolecule Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Cry-Per Complex F-box Domain Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Glucocorticoid Secretion Circadian Rhythm Cul7-RING Ubiquitin Ligase Complex Membrane Curvature Sensor Activity Regulation Of Sodium-dependent Phosphate Transport Response To Blue Light Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Repair Branchiomotor Neuron Axon Guidance Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of Actin Nucleation Regulation Of Phosphate Transport Pyrimidine Dimer Repair Photoreceptor Activity Protein Domain Specific Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Nucleus Negative Regulation Of Circadian Rhythm Ubiquitin Ligase Activator Activity Neuronal Ion Channel Clustering Dendritic Spine Maintenance Regulation Of Axon Guidance Ubiquitin-protein Transferase Activity Rhythmic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction
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