FBXL3 and UBE2D2

Number of citations of the paper that reports this interaction (PMID 10531035)
89

Data Source:
BioGRID (enzymatic study)

		FBXL3	UBE2D2
Gene Name		F-box and leucine-rich repeat protein 3	ubiquitin-conjugating enzyme E2D 2
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Nucleoplasm Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Circadian Rhythm Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod	Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Cellular Response To Hypoxia
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		3 interactors: CDC34 SKP1 UBE2D2	167 interactors: AMFR ANAPC11 ARIH2 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BRCA1 BTRC CADPS2 CBL CBLC CCNB1 CDKN1B CHFR CNOT4 CUL3 DDX58 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 FZR1 HERC4 HUWE1 ITCH KCMF1 LNX1 LRSAM1 LTN1 MAP3K1 MAPT MARCH3 MARCH5 MARCH6 MARCH7 MDM2 MDM4 MGRN1 MIB1 MID1 MKRN3 MUL1 MYLIP NEDD4 NEDD4L NFKBIA NHLRC1 NSMCE1 OTUB1 PARK2 PDZRN3 PELI1 PJA1 PJA2 POLL POLM QSOX1 RAF1 RAG1 RBX1 RCHY1 RELA RFFL RFWD2 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF146 RNF150 RNF151 RNF165 RNF166 RNF167 RNF181 RNF185 RNF186 RNF2 RNF25 RNF26 RNF34 RNF38 RNF4 RNF43 RNF5 RNF7 RSPRY1 SIAH1 SIAH2 SOCS6 STAM2 STK11 STUB1 SYVN1 TOPORS TRAF6 TRAF7 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM5 TRIM50 TRIM55 TRIM63 TRIM7 TRIM8 TTC3 UBA1 UBA6 UBASH3B UBC UBE3A UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF2 VPRBP VPS18 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		26224	7322
HPRD ID		05737	04268
Ensembl ID		ENSG00000005812	ENSG00000131508
Uniprot IDs		Q9UKT7	P62837
PDB IDs		4I6J	1UR6 1W4U 2C4O 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Catabolic Process Positive Regulation Of Inclusion Body Assembly Negative Regulation Of CAMP-mediated Signaling Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of Inclusion Body Assembly Mitotic Cell Cycle Process Cellular Protein Modification Process Histone Monoubiquitination Regulation Of CAMP-mediated Signaling Mitotic Cell Cycle SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Replication Initiation Histone Ubiquitination Protein Monoubiquitination Cell Cycle Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Positive Regulation Of Neuron Death Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Polyubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Protein Monoubiquitination Metabolic Process Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Innate Immune Response Regulation Of Protein Catabolic Process Cellular Process Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Cell Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Viral Process Cell Death Regulation Of Proteolysis Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Signaling
Tagcloud ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon frameshift med8 microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	actb aging analysed comprehensive cows deltact differed dominant durations eif2b2 follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold
Tagcloud (Difference) ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon frameshift med8 microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	actb aging analysed comprehensive cows deltact differed dominant durations eif2b2 follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold
Tagcloud (Intersection) ?