SPEN and MBD3

Number of citations of the paper that reports this interaction (PMID 11331609)
70

Data Source:
HPRD (in vivo)

		SPEN	MBD3
Gene Name		spen family transcriptional repressor	methyl-CpG binding domain protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcriptional Repressor Complex Extracellular Vesicular Exosome	Nuclear Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Methylation-dependent Chromatin Silencing Transcription, DNA-templated Tissue Development Histone Acetylation ATP-dependent Chromatin Remodeling
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ATXN1 CTBP1 DLX5 HDAC1 HDAC2 HRSP12 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RUNX1 RUNX1T1 SERTAD1 SOX9 UBE2L6	28 interactors: AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 HDAC1 HIST3H3 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA1 MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZNF277
Entrez ID		23013	53615
HPRD ID		10230	04653
Ensembl ID		ENSG00000065526	ENSG00000071655
Uniprot IDs		Q96T58	O95983
PDB IDs		1OW1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Organization ATP-dependent Chromatin Remodeling Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Chromatin Remodeling Positive Regulation Of Gene Expression Hair Follicle Development Hair Cycle Process Limb Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Chromatin Modification Response To Growth Factor Hair Cycle Tissue Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Organ Morphogenesis	ATP-dependent Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromatin Organization Transcription, DNA-templated Chromosome Organization Chromatin Modification RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Remodeling RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification Histone Modification Negative Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Interaction With Symbiont Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3-K4 Demethylation Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Binding
Tagcloud ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Difference) ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Intersection) ?