SPEN and RBPJ

Number of citations of the paper that reports this interaction (PMID 12374742)
50

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SPEN	RBPJ
Gene Name		spen family transcriptional repressor	recombination signal binding protein for immunoglobulin kappa J region
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcriptional Repressor Complex Extracellular Vesicular Exosome	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	Recombinase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation DNA Recombination Transcription Initiation From RNA Polymerase II Promoter Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Negative Regulation Of Cell Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Gene Expression Pituitary Gland Development B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Timing Of Cell Differentiation Sebaceous Gland Development Hair Follicle Maturation Positive Regulation Of Cardiac Muscle Cell Proliferation Clara Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Notch Signaling Involved In Heart Development Blood Vessel Lumenization Interleukin-4 Secretion Blood Vessel Endothelial Cell Fate Specification Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		20 interactors: ATXN1 CTBP1 DLX5 HDAC1 HDAC2 HRSP12 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RUNX1 RUNX1T1 SERTAD1 SOX9 UBE2L6	24 interactors: APP CIR1 FHL1 GADD45A GSK3B HDAC1 HMGB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A RPS6KA6 SIN3A SND1 SNW1 SPEN SUFU
Entrez ID		23013	3516
HPRD ID		10230	00920
Ensembl ID		ENSG00000065526	ENSG00000168214
Uniprot IDs		Q96T58	Q06330
PDB IDs		1OW1	2F8X 3NBN 3V79
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Organization ATP-dependent Chromatin Remodeling Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Chromatin Remodeling Positive Regulation Of Gene Expression Hair Follicle Development Hair Cycle Process Limb Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Chromatin Modification Response To Growth Factor Hair Cycle Tissue Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Organ Morphogenesis	Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Developmental Process Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated System Development Anatomical Structure Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nervous System Development Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Cell Differentiation Organ Development Central Nervous System Development Negative Regulation Of Cell Differentiation Regulation Of Cellular Process Positive Regulation Of Metabolic Process
Tagcloud ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch numb numbl oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch numb numbl oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?