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SPEN
Gene Name
spen family transcriptional repressor
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Transcriptional Repressor Complex
Extracellular Vesicular Exosome
Molecular Function
Nucleotide Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
Single-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Notch Signaling Pathway
Viral Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Neurogenesis
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions
20 interactors:
ATXN1
CTBP1
DLX5
HDAC1
HDAC2
HRSP12
MBD3
MSX2
MTA2
NCOR1
NCOR2
PPARD
RARA
RBBP4
RBPJ
RUNX1
RUNX1T1
SERTAD1
SOX9
UBE2L6
Entrez ID
23013
HPRD ID
10230
Ensembl ID
ENSG00000065526
Uniprot IDs
Q96T58
PDB IDs
1OW1
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Cell Proliferation
Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Chromatin Organization
ATP-dependent Chromatin Remodeling
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Embryo Development
Chromatin Remodeling
Positive Regulation Of Gene Expression
Hair Follicle Development
Hair Cycle Process
Limb Development
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Modification
Response To Growth Factor
Hair Cycle
Tissue Development
DNA-templated Transcription, Initiation
Negative Regulation Of Cell Proliferation
Organ Morphogenesis
Tagcloud
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15q25
5p15
6p21
adca
bag6
ebln2
entirely
exome
germline
gon4l
gwas
kiaa2018
nelfe
nop58
players
polygenic
predispose
predisposition
rbmx
reproducible
sib
sibling
sibs
smokers
taf1b
tceb3c
truncating
wisp3
znf311