SPEN and DLX5

Number of citations of the paper that reports this interaction (PubMedID 10451362)
0

Data Source:
HPRD (in vitro)

		SPEN	DLX5
Description		spen family transcriptional repressor	distal-less homeobox 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome	Chromatin Nucleus Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Neurogenesis Random Inactivation Of X Chromosome	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Head Development Face Morphogenesis Bone Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance
Pathways		RHOBTB1 GTPase cycle	Regulation of RUNX2 expression and activity Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)	Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning vs. evening chronotype ( 26835600)
Interacting Genes		24 interacting genes: ATXN1 CLK1 CRK CTBP1 DLX5 HDAC1 HDAC2 ITCH MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6	9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		23013	1749
HPRD ID		10230	02492
Ensembl ID		ENSG00000065526	ENSG00000105880
Uniprot IDs		Q96T58	P56178 Q53Y73
PDB IDs		1OW1 2RT5 4P6Q 7Z1K	2DJN 4RDU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Stem Cell Differentiation NuRD Complex Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Cell Population Proliferation Histone Deacetylase Binding Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein-containing Complex Regulation Of Cell Differentiation Nucleosomal DNA Binding Histone Deacetylase Complex DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Transcription Cis-regulatory Region Binding Regulation Of Developmental Process Regulation Of MiRNA Transcription Nucleoplasm DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Morphogenesis Of A Branching Structure Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Oligodendrocyte Differentiation Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Positive Regulation Of Multicellular Organismal Process Activation Of Meiosis Animal Organ Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Regulation Of Multicellular Organismal Process Transcription Cis-regulatory Region Binding Regionalization Regulation Of Gene Expression Regulation Of Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Binding Regulation Of Primary Metabolic Process Mammary Gland Epithelium Development Odontogenesis Mesenchymal Cell Apoptotic Process Enteric Nervous System Development Regulation Of Gliogenesis Cartilage Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Glial Cell Differentiation Regulation Of Multicellular Organismal Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Regulation Of Neurogenesis
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