SPEN and DLX5

Number of citations of the paper that reports this interaction (PMID 10451362)
29

Data Source:
HPRD (in vitro)

		SPEN	DLX5
Gene Name		spen family transcriptional repressor	distal-less homeobox 5
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcriptional Repressor Complex Extracellular Vesicular Exosome	Nuclear Chromatin Cytoplasm
	Molecular Function	Nucleotide Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Regulatory Region DNA Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Transcription, DNA-templated Nervous System Development Axon Guidance Cell Proliferation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Palate Development Olfactory Pit Development Face Morphogenesis Cellular Response To BMP Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ATXN1 CTBP1 DLX5 HDAC1 HDAC2 HRSP12 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RUNX1 RUNX1T1 SERTAD1 SOX9 UBE2L6	9 interactors: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		23013	1749
HPRD ID		10230	02492
Ensembl ID		ENSG00000065526	ENSG00000105880
Uniprot IDs		Q96T58	P56178 Q53Y73
PDB IDs		1OW1	2DJN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Organization ATP-dependent Chromatin Remodeling Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Chromatin Remodeling Positive Regulation Of Gene Expression Hair Follicle Development Hair Cycle Process Limb Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Chromatin Modification Response To Growth Factor Hair Cycle Tissue Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Organ Morphogenesis	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Mesenchymal Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Mesenchyme Development Activation Of Meiosis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process BMP Signaling Pathway Involved In Heart Development Connective Tissue Development Stem Cell Development Skeletal System Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Differentiation Nail Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Gliogenesis Transcription From RNA Polymerase II Promoter Odontogenesis Of Dentin-containing Tooth Enteric Nervous System Development Odontogenesis Organ Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Meiotic Nuclear Division Endocardial Cushion Formation RNA Metabolic Process Embryo Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Tagcloud ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311	acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby
Tagcloud (Difference) ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311	acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby
Tagcloud (Intersection) ?