SPEN and SERTAD1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPEN	SERTAD1
Gene Name		spen family transcriptional repressor	SERTA domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcriptional Repressor Complex Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ATXN1 CTBP1 DLX5 HDAC1 HDAC2 HRSP12 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RUNX1 RUNX1T1 SERTAD1 SOX9 UBE2L6	36 interactors: ASB8 ATXN7L3 CCND2 CDK4 CDKN2A CHURC1 CIB3 COPB1 CREBBP DENND4A EGLN3 EP300 FAH HIVEP1 HSPB1 KAT2B KLHL42 MVP P4HA3 PATE1 POT1 PRDM4 RBX1 RCHY1 ROPN1 SETD7 SFI1 SMAD3 SPEN STAT5B SUPT7L TCEB1 TGM2 TLR4 TRIM28 ZNF410
Entrez ID		23013	29950
HPRD ID		10230	15326
Ensembl ID		ENSG00000065526
Uniprot IDs		Q96T58	Q53GC0 Q9UHV2
PDB IDs		1OW1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Organization ATP-dependent Chromatin Remodeling Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Chromatin Remodeling Positive Regulation Of Gene Expression Hair Follicle Development Hair Cycle Process Limb Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Chromatin Modification Response To Growth Factor Hair Cycle Tissue Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Organ Morphogenesis	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Response To Hypoxia Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Oxygen Levels N-terminal Protein Amino Acid Acetylation Viral Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Notch Signaling Pathway Negative Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Protein Metabolic Process Chromatin Organization Chromosome Organization Positive Regulation Of Interleukin-1 Production N-terminal Protein Amino Acid Modification Positive Regulation Of Cytokine Production Response To Abiotic Stimulus
Tagcloud ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311
Tagcloud (Difference) ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311
Tagcloud (Intersection) ?